Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.35 |
| ▸ | ASPH | Q12797 | 1/20 | 0.35 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19698928 | 0.86 | HCAR2 (0.43) | HCAR2HCAR3KDM4EALDH1A1ALOX15 | |
| SCHEMBL21452962 | 0.78 | HCAR3 (0.38) | HCAR2HCAR3MAPK1GCKVNN1 | |
| SCHEMBL22304409 | 0.74 | AGBL2 (0.30) | — | |
| SCHEMBL22060645 | 0.73 | HCAR2 (0.41) | HCAR2HCAR3KDM4EALDH1A1ALOX15 | |
| SCHEMBL114191 | 0.73 | HCAR2 (0.47) | HCAR2HCAR3KDM4EALDH1A1ALOX15 | |
| SCHEMBL30721127 | 0.72 | HCAR2 (0.50) | HCAR2KDM4EALDH1A1ALOX15HSD17B10 | |
| SCHEMBL898595 | 0.72 | HCAR2 (0.50) | HCAR2KDM4EALDH1A1ALOX15HSD17B10 | |
| SCHEMBL1420763 | 0.72 | KCNQ3 (0.42) | HCAR2HCAR3ALDH1A1LMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL17785057 | 0.72 | HCAR2 (0.46) | HCAR2HCAR3KDM4EALDH1A1ALOX15 | |
| SCHEMBL19105598 | 0.71 | HPGDS (0.41) | LMNAVNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3587412-B1 | FXR (NR1H4) MODULATING COMPOUNDS | GILEAD SCIENCES INC (US) | 2022-05-25 | — | — | EP | disclosed |