Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL244507 | 1.00 | CYP3A4 (0.51) | CYP3A4CYP2D6CYP2C9CYP2C19SIGMAR1 | |
| SCHEMBL244506 | 1.00 | CYP3A4 (0.51) | CYP3A4CYP2D6CYP2C9CYP2C19SIGMAR1 | |
| SCHEMBL4759499 | 1.00 | CYP3A4 (0.51) | CYP3A4CYP2D6CYP2C9CYP2C19SIGMAR1 | |
| SCHEMBL245107 | 0.81 | — | — | |
| SCHEMBL246854 | 0.81 | — | — | |
| SCHEMBL244066 | 0.81 | — | — | |
| SCHEMBL245106 | 0.81 | — | — | |
| SCHEMBL246281 | 0.79 | — | — | |
| SCHEMBL246280 | 0.79 | — | — | |
| SCHEMBL246282 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937189-B2 | Tri-substituted 2-benzhydryl-5-benzylamino-tetrahydro-pyran-4-ol and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-ol analogues, and novel 3,6-disubstituted pyran derivatives | WAYNE STATE UNIVERSITY (US) | 2015-01-20 | — | — | US | disclosed |
| US-8841464-B2 | Tri-substituted 2-benzhydryl-5-benzylamino-tetrahydro-pyran-4-ol and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-ol analogues, and novel 3,6-disubstituted pyran derivatives | WAYNE STATE UNIVERSITY (US) | 2014-09-23 | — | — | US | disclosed |
| EP-1734948-B1 | TRI-SUBSTITUED 2-BENZHYDRYL-5-BENZYLAMINO-TETRAHYDRO-PYRAN-4-OL AND 6-BENZHYDRYL-4-BENZYLAMINO-TETRAHYDRO-PYRAN-3-OL ANALOGUES, AND NOVEL 3,6-DISUBSTITUTED PYRAN DERIVATIVES | UNIV WAYNE STATE (US) | 2014-06-11 | — | — | EP | disclosed |
| US-20140058120-A1 | TRI-SUBSTITUTED 2-BENZHYDRYL-5-BENZYLAMINO-TETRAHYDRO-PYRAN-4-OL AND 6-BENZHYDRYL-4-BENZYLAMINO-TETRAHYDRO-PYRAN-3-OL ANALOGUES, AND NOVEL 3,6-DISUBSTITUTED PYRAN DERIVATIVES | WAYNE STATE UNIVERSITY (US) | 2014-02-27 | — | — | US | disclosed |
| US-8519159-B2 | Tri-substituted 2-benzhydryl-5-benzylamino-tetrahydro-pyran-4-OL and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-OL analogues, and novel 3,6-disubstituted pyran derivatives | WAYNE STATE UNIVERSITY (US) | 2013-08-27 | — | — | US | disclosed |
| EP-1976381-B1 | TRI-SUBSTITUTED 2-BENZHYDRYL-5-BENZLAMINO-TETRAHYDRO-PYRAN-4-OL AND 6-BENZHYDRYL-4-BENZYLAMINO-TETRAHYDRO-PYRAN-3-OL ANALOGUES, AND NOVEL 3,6-DISUBSTITUTED PYRAN DERIVATIVES | UNIV WAYNE STATE (US) | 2013-07-24 | — | — | EP | disclosed |
| US-20120004428-A1 | Tri-Substituted 2-Benzhydryl-5-Benzylamino-Tetrahydro-Pyran-4-OL and 6-Benzhydryl-4-Benzylamino-Tetrahydro-Pyran-3-OL Analogues, and Novel 3,6-Disubstituted Pyran Derivatives | WAYNE STATE UNIVERSITY (US) | 2012-01-05 | — | — | US | disclosed |
| US-8017791-B2 | Tri-substituted 2-benzhydryl-5-benzylamino-tetrahydro-pyran-4-ol and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-ol analogues, and novel, 3,6-disubstituted pyran derivatives | WAYNE STATE UNIVERSITY (US) | 2011-09-13 | — | — | US | disclosed |
| US-7915433-B2 | Tri-substituted 2-benzhydryl 5-benzlamino-tetrahydro-pyran-4-OL and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-OL analogues, and novel 3,6 disubstituted pyran derivatives | WAYNE STATE UNIVERSITY (US) | 2011-03-29 | — | — | US | disclosed |
| US-20100280091-A1 | TRI-SUBSTITUTED 2-BENZHYDRYL-5-BENZYLAMINO-TETRAHYDRO-PYRAN-4-OL AND 6-BENZHYDRYL-4-BENZYLAMINO-TETRAHYDRO-PYRAN-3-OL ANALOGUES, AND NOVEL 3,6-DISBUSTITUTED PYRAN DERIVATIVES | WAYNE STATE UNIVERSITY (US) | 2010-11-04 | — | — | US | disclosed |
| EP-1976381-A2 | TRI-SUBSTITUTED 2-BENZHYDRYL-5-BENZLAMINO-TETRAHYDRO-PYRAN-4-OL AND 6-BENZHYDRYL-4-BENZYLAMINO-TETRAHYDRO-PYRAN-3-OL ANALOGUES, AND NOVEL 3,6-DISUBSTITUTED PYRAN DERIVATIVES | WAYNE STATE UNIVERSITY (US) | 2008-10-08 | — | — | EP | disclosed |
| US-20080167478-A1 | Tri-Substituted 2-Benzhydryl-5-Benzlamino-Tetrahydro-Pyran-4-OL and 6-Benzhydryl-4-Benzylamino-Tetrahydro-Pyran-3-OL Analogues, and Novel 3,6-Disubstituted Pyran Derivatives | WAYNE STATE UNIVERSITY (US) | 2008-07-10 | — | — | US | disclosed |
| US-20070276005-A1 | TRI-SUBSTITUED 2-BENZHYDRYL 5-BENZLAMINO-TETRAHYDRO-PYRAN-4-OL AND 6-BENZHYDRYL-4-BENZYLAMINO-TETRAHYDRO-PYRAN-3-OL ANALOGUES, AND NOVEL 3,6 DISUBSTITUTED PYRAN DERIVATIVES | WAYNE STATE UNIVERSITY (US) | 2007-11-29 | — | — | US | disclosed |
| WO-2007082292-A2 | TRI-SUBSTITUTED 2-BENZHYDRYL-5-BENZLAMINO-TETRAHYDRO-PYRAN-4-OL AND 6-BENZHYDRYL-4-BENZYLAMINO-TETRAHYDRO-PYRAN-3-OL ANALOGUES, AND NOVEL 3,6-DISUBSTITUTED PYRAN DERIVATIVES | WAYNE STATE UNIVERSITY (US) | 2007-07-19 | — | — | WO | disclosed |
| US-20060122263-A1 | Tri-substituted 2-benzhydryl-5-benzlamino-tetrahydro-pyran-4-ol and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-ol analogues, and novel 3,6-disubstituted pyran derivatives | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122263-A1 | Tri-substituted 2-benzhydryl-5-benzlamino-tetrahydro-pyran-4-ol and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-ol analogues, and novel 3,6-disubstituted pyran derivatives | TPH1, TPH2, HTR4 | CYP3A4 89/4885CYP2D6 71/4885CYP2C9 173/4885 |
| US-20120004428-A1 | Tri-Substituted 2-Benzhydryl-5-Benzylamino-Tetrahydro-Pyran-4-OL and 6-Benzhydryl-4-Benzylamino-Tetrahydro-Pyran-3-OL Analogues, and Novel 3,6-Disubstituted Pyran Derivatives | TPH1, HTR4, TPH2 | CYP3A4 90/4885CYP2D6 68/4885CYP2C9 197/4885 |
| US-20080167478-A1 | Tri-Substituted 2-Benzhydryl-5-Benzlamino-Tetrahydro-Pyran-4-OL and 6-Benzhydryl-4-Benzylamino-Tetrahydro-Pyran-3-OL Analogues, and Novel 3,6-Disubstituted Pyran Derivatives | TPH1, TPH2, HTR4 | CYP3A4 89/4885CYP2D6 71/4885CYP2C9 173/4885 |
| US-20140058120-A1 | TRI-SUBSTITUTED 2-BENZHYDRYL-5-BENZYLAMINO-TETRAHYDRO-PYRAN-4-OL AND 6-BENZHYDRYL-4-BENZYLAMINO-TETRAHYDRO-PYRAN-3-OL ANALOGUES, AND NOVEL 3,6-DISUBSTITUTED PYRAN DERIVATIVES | TPH1, HTR4, TPH2 | CYP3A4 90/4885CYP2D6 68/4885CYP2C9 197/4885 |
| US-20100280091-A1 | TRI-SUBSTITUTED 2-BENZHYDRYL-5-BENZYLAMINO-TETRAHYDRO-PYRAN-4-OL AND 6-BENZHYDRYL-4-BENZYLAMINO-TETRAHYDRO-PYRAN-3-OL ANALOGUES, AND NOVEL 3,6-DISBUSTITUTED PYRAN DERIVATIVES | TPH1, TPH2, HTR4 | CYP3A4 88/4885CYP2D6 68/4885CYP2C9 205/4885 |
| US-20070276005-A1 | TRI-SUBSTITUED 2-BENZHYDRYL 5-BENZLAMINO-TETRAHYDRO-PYRAN-4-OL AND 6-BENZHYDRYL-4-BENZYLAMINO-TETRAHYDRO-PYRAN-3-OL ANALOGUES, AND NOVEL 3,6 DISUBSTITUTED PYRAN DERIVATIVES | TPH1, TPH2, HTR4 | CYP3A4 113/4885CYP2D6 76/4885CYP2C9 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.