SCHEMBL24452008

SCHEMBL24452008

c1ccc(-c2cccc([Si](c3ccccc3)(c3ccccc3)c3cc(-c4ccccc4)cc(-c4ccc5nc6n(c5c4)-c4ccccc4OC6)c3)c2)cc1

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
THRB P10828 2/20 0.34
MAPT P10636 1/20 0.33
GRM5 P41594 1/20 0.31
LMNA P02545 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24452011 1.00 THRB (0.34) THRBMAPTGRM5LMNAHPGD
SCHEMBL24452006 0.97 THRB (0.35) THRBMAPTGRM5LMNAHPGD
SCHEMBL24452013 0.96 THRB (0.36) THRBMAPTGRM5LMNAHPGD
SCHEMBL24452162 0.92 THRB (0.34) THRBMAPTGRM5LMNAHPGD
SCHEMBL24451431 0.88 CYP11B1 (0.31) THRBMAPT
SCHEMBL24452012 0.86 CHEK2 (0.33) THRBMAPT
SCHEMBL24452216 0.85 THRB (0.30) THRB
SCHEMBL24451432 0.84 MAPT (0.33) THRBMAPT
SCHEMBL24451438 0.84 MAPT (0.33) THRBMAPT
SCHEMBL24452031 0.83 MAPT (0.33) THRBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220165960-A1 HETEROCYCLIC COMPOUND, LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND ELECTRONIC APPARATUS INCLUDING THE LIGHT-EMITTING DEVICE SAMSUNG DISPLAY CO., LTD. (KR) 2022-05-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220165960-A1 HETEROCYCLIC COMPOUND, LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND ELECTRONIC APPARATUS INCLUDING THE LIGHT-EMITTING DEVICE CRY1, CYP1A1, CRY2 THRB 4498/4885MAPT 3371/4885GRM5 2089/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.