Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 4/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 2/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL949635 | 0.80 | HTR6 (0.55) | DRD2HTR2AHTR6USP30ALDH1A1 | |
| SCHEMBL17580774 | 0.78 | HRH3 (0.43) | DRD2HTR2AHTR6 | |
| SCHEMBL2450284 | 0.77 | HTR6 (0.47) | DRD2HTR2AHTR6 | |
| SCHEMBL17580742 | 0.77 | HTR6 (0.41) | DRD2HTR2AHTR6ALDH1A1KMT2A | |
| SCHEMBL2448414 | 0.77 | HTR6 (0.44) | DRD2HTR2AHTR6 | |
| SCHEMBL23121307 | 0.71 | TLR9 (0.43) | DRD2USP30ALDH1A1KDM4E | |
| SCHEMBL31066834 | 0.71 | HPGDS (0.44) | DRD2HTR2AUSP30ALDH1A1 | |
| SCHEMBL2448448 | 0.69 | HTR6 (0.50) | DRD2HTR2AHTR6 | |
| SCHEMBL4688099 | 0.69 | HTR6 (0.43) | DRD2HTR2AHTR6 | |
| SCHEMBL6023725 | 0.69 | MEN1 (0.68) | DRD2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139880-B1 | QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR | ABBOTT GMBH & CO KG (DE) | 2011-09-14 | — | — | EP | claimed |