Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 16/20 | 0.50 |
| ▸ | HTR7 | P34969 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2450284 | 0.86 | HTR6 (0.47) | HTR6HTR7HTR2AHTR1ADRD2 | |
| SCHEMBL2450686 | 0.83 | HTR6 (0.40) | HTR6HTR7HTR2AHTR1ADRD2 | |
| SCHEMBL952720 | 0.82 | HTR6 (0.55) | HTR6HTR7HTR2AHTR1ADRD2 | |
| SCHEMBL2446379 | 0.80 | HTR2C (0.52) | HTR6 | |
| SCHEMBL2450688 | 0.79 | HTR6 (0.45) | HTR6HTR7HTR2AHTR1ADRD2 | |
| SCHEMBL4690981 | 0.77 | HTR6 (0.61) | HTR6HTR7HTR2AHTR1ADRD2 | |
| SCHEMBL3136898 | 0.77 | HTR6 (0.60) | HTR6HTR7HTR2AHTR1ADRD2 | |
| SCHEMBL2448414 | 0.74 | HTR6 (0.44) | HTR6HTR7HTR2AHTR1ADRD2 | |
| SCHEMBL17580792 | 0.74 | HTR6 (0.42) | HTR6HTR7HTR2AHTR1ADRD2 | |
| SCHEMBL9902743 | 0.71 | HTR6 (0.50) | HTR6HTR7HTR2AHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139880-B1 | QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR | ABBOTT GMBH & CO KG (DE) | 2011-09-14 | — | — | EP | claimed |