Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 5/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.30 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29551627 | 0.82 | CDC7 (0.32) | CDC7DBF4PARP10PARP1 | |
| SCHEMBL29551711 | 0.78 | IL4I1 (0.34) | CDC7DBF4 | |
| SCHEMBL24457495 | 0.77 | CDC7 (0.30) | CDC7DBF4 | |
| SCHEMBL24457327 | 0.77 | CDC7 (0.30) | CDC7DBF4 | |
| SCHEMBL24457369 | 0.76 | PARP10 (0.46) | PARP10PARP11PARP1 | |
| SCHEMBL12077241 | 0.76 | TDP2 (0.46) | CDC7DBF4KDM4EPARP10PARP11 | |
| SCHEMBL31351736 | 0.76 | TDP2 (0.40) | CDC7DBF4KDM4EPARP1HPGD | |
| SCHEMBL27445501 | 0.76 | SMN1; SMN2 (0.39) | CDC7DBF4KDM4EPARP11PARP1 | |
| SCHEMBL12078031 | 0.73 | BACE1 (0.38) | CDC7DBF4 | |
| SCHEMBL24457584 | 0.73 | PARP10 (0.50) | CDC7DBF4PARP10PARP11PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330236-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | Denali Therapeutics Inc. (US) | 2024-03-06 | — | — | EP | disclosed |
| EP-4247376-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | Denali Therapeutics Inc. (US) | 2023-09-27 | — | — | EP | disclosed |
| WO-2022232632-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | DENALI THERAPEUTICS INC. (US) | 2022-11-03 | — | — | WO | disclosed |
| WO-2022109268-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | DENALI THERAPEUTICS INC. (US) | 2022-05-27 | — | — | WO | disclosed |
| WO-2022109268-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | DENALI THERAPEUTICS INC. (US) | 2022-05-27 | — | — | WO | disclosed |