Isosorbide

Isosorbide

SCHEMBL244589

OC1COC2C(O)COC12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 1.00
LMNA P02545 1/20 1.00
MAPT P10636 1/20 0.48
BCHE P06276 1/20 0.33
FUCA1 P04066 1/20 0.30
GBA1 P04062 1/20 0.30
GLA P06280 1/20 0.30
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isosorbide SCHEMBL9882796 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL6298736 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
SCHEMBL17023940 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL6105354 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL196402 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL346855 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL24465084 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL15440712 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL1918479 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL13938288 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2082 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12637599-B2 Two-component polyurethane adhesive composition for film lamination in hot filling application HENKEL AG & CO. KGAA (DE) 2026-05-26 US claimed
EP-4263668-B1 BIO-BASED SULFONE COPOLYMERS FREE OF BPA AND BPS SYENSQO SPECIALTY POLYMERS USA LLC (US) 2026-04-22 EP claimed
US-20260103568-A1 POLYARYLETHERSULFONE COPOLYMER HAVING IMPROVED HYDROPHILICITY SYENSQO SPECIALTYY POLYMRES USA LLC (US) 2026-04-16 US claimed
US-12577447-B2 Two-component polyurethane adhesive composition for film lamination HENKEL AG & CO. KGAA (DE) 2026-03-17 US claimed
US-20260062510-A1 POLYOL COMPOSITION AND PREPARATION METHOD THEREFOR, COMPOSITION FOR POLYURETHANE PREPARATION COMPRISING POLYOL COMPOSITION, AND BATTERY MODULE PUCORE CO LTD (KR) 2026-03-05 US claimed
EP-3822299-B1 BIO-BASED POLYCARBONATE ESTER RESIN FOR EYEGLASS FRAME SK CHEMICALS CO LTD (KR) 2026-02-18 EP claimed
EP-4178784-B1 THERMOPLASTIC POLYESTER FOR PRODUCING 3D-PRINTED OBJECTS ROQUETTE FRERES (FR) 2026-02-11 EP claimed
EP-4178785-B1 THERMOPLASTIC POLYESTER FOR PRODUCING 3D-PRINTED OBJECTS ROQUETTE FRERES (FR) 2026-02-11 EP claimed
US-12534568-B2 Polyester carbonates consisting of different diols in a defined ratio COVESTRO DEUTSCHLAND AG (DE) 2026-01-27 US claimed
US-12516152-B2 Polyester carbonates having a defined proportion of ester groups COVESTRO DEUTSCHLAND AG (DE) 2026-01-06 US claimed
US-20060177416-A1 Polymer particle delivery compositions and methods of use MEDIVAS, LLC (US) 2006-08-10 US claimed
WO-2006083874-A2 VACCINE DELIVERY COMPOSITIONS AND METHODS OF USE MEDIVAS, LLC. (US) 2006-08-10 WO claimed
WO-2006050091-A2 BIOACTIVE WOUND DRESSINGS AND IMPLANTABLE DEVICES AND METHODS OF USE MEDIVAS, LLC (US) 2006-05-11 WO claimed
US-20060024357-A1 Wound healing polymer compositions and methods for use thereof MEDIVAS, LLC (US) 2006-02-02 US claimed
US-20060013855-A1 Bioactive stents for type II diabetics and methods for use thereof MEDIVAS, LLC (US) 2006-01-19 US claimed
US-20050238689-A1 Bioactive stents for type II diabetics and methods for use thereof MEDIVAS, LLC (US) 2005-10-27 US claimed
WO-2005097186-A2 BIOACTIVE STENTS FOR TYPE II DIABETICS AND METHODS FOR USE THEREOF MEDIVAS, LLC (US) 2005-10-20 WO claimed
EP-0167008-B1 1,4:3,6-DIANHYDRO-HEXITE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS Heinrich Mack Nachf. (DE) 1989-09-06 EP claimed
EP-0114270-B1 ACYL DERIVATIVES OF 1,4:3,6-DIANHYDRO-HEXITOLES, METHOD FOR THEIR PREPARATION AND THEIR PHARMAZEUTICAL USE Heinrich Mack Nachf. (DE) 1987-04-01 EP claimed
EP-0025937-B1 THERMOPLASTIC POLYCARBONATES, PROCESS FOR THEIR PREPARATION, BIS-HALO-FORMATES OF HEXAHYDRO-FURO (3,2-B) FURAN-3,6-DIOLS, AND POLYCARBONATE COMPOSITIONS BAYER AG (DE) 1983-08-17 EP claimed