Isosorbide

Isosorbide

SCHEMBL346855

O[C@H]1CO[C@H]2[C@@H]1OC[C@@H]2O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 1.00
LMNA P02545 1/20 1.00
MAPT P10636 1/20 0.48
BCHE P06276 1/20 0.33
FUCA1 P04066 1/20 0.30
GBA1 P04062 1/20 0.30
GLA P06280 1/20 0.30
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isosorbide SCHEMBL9882796 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL6298736 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
SCHEMBL17023940 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL6105354 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL196402 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL24465084 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL15440712 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL244589 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL1918479 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL13938288 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1905 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122080382-A Isosorbide type polycarbonate and preparation method thereof 2026-05-26 CN claimed
EP-4296325-B1 COATING COMPOSITION, FOR METAL, WITH IMPROVED OIL RESISTANCE AND ADHESIVENESS AND A PREPARATION METHOD THEREFOR, AND A METAL ARTICLE COATED WITH COMPOSITION SAMYANG CORP (KR) 2026-05-13 EP claimed
EP-4731727-A1 HALF-WAVE PLATE Merck Patent GmbH (DE) 2026-04-29 EP claimed
EP-4263668-B1 BIO-BASED SULFONE COPOLYMERS FREE OF BPA AND BPS SYENSQO SPECIALTY POLYMERS USA LLC (US) 2026-04-22 EP claimed
US-20260098118-A1 Non-Softening Thermoplastic Polyurethanes LUBRIZOL ADVANCED MATERIALS, INC. (US) 2026-04-09 US claimed
EP-4720199-A1 SELF-CROSSLINKABLE URETHANE (METH)ACRYLATES ARKEMA France (FR) 2026-04-08 EP claimed
US-20260092174-A1 COMPOSITION FOR FORMING ECO-FRIENDLY POLYURETHANE FOAM HAVING IMPROVED INSULATION PROPERTIES AND METHOD FOR PREPARING POLYURETHANE FOAM SAMYANG CORPORATION (KR) 2026-04-02 US claimed
EP-3643732-B1 COMPOSITION FOR FORMING ENVIRONMENTALLY FRIENDLY POLYURETHANE FOAM AND METHOD FOR MANUFACTURING POLYURETHANE FOAM SAMYANG CORP (KR) 2026-04-01 EP claimed
EP-4713413-A1 CHIRAL REACTIVE MESOGEN MIXTURE Merck Patent GmbH (DE) 2026-03-25 EP claimed
EP-4713414-A1 OPTICAL ELEMENT COMPRISING A CHIRAL LC POLYMER FILM Merck Patent GmbH (DE) 2026-03-25 EP claimed
US-20150031828-A1 BIOBASED ALKYD RESIN AND PROCESS FOR MANUFACTURING SUCH AN ALKYD RESIN ROQUETTE FRERES (FR) 2015-01-29 US claimed
US-20140023725-A1 Biocompatible, Biodegradable Polyurethane Materials With Controlled Hydrophobic to Hydrophilic Ratio DePuy Synthes Products, LLC (US) 2014-01-23 US claimed
US-8460378-B2 Use as scaffolds, tissue engineering, bone repair, drug delivery; polyurethane derived from biocompatible biodegradable polyols, polyisocyanates, and low molecular weight chain extenders having functionality of two or higher; can be derived from sugar or soy-based ingredients DePuy Sythes Products, LLC (US) 2013-06-11 US claimed
US-20080262613-A1 Biocompatible, Biodegradable Polyurethane Materials With Controlled Hydrophobic to Hydrophilic Ratio SYNTHES USA, LLC 2008-10-23 US claimed
EP-0604459-A1 Organic nitrates, methods for preparing same and use thereof for treating cardiovascular diseases LABORATOIRES HOECHST S.A. (FR) 1994-07-06 EP claimed
EP-0530887-A1 Organic nitrates, processes for their preparation and their use in the treatment of cardiovascular diseases LABORATOIRES HOECHST S.A. (FR) 1993-03-10 EP claimed
WO-1993003037-A1 ORGANIC NITRATES, METHODS FOR PREPARING SAME AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES LABORATOIRES HOECHST, SOCIÉTÉ ANONYME (FR) 1993-02-18 WO claimed
EP-0167008-B1 1,4:3,6-DIANHYDRO-HEXITE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS Heinrich Mack Nachf. (DE) 1989-09-06 EP claimed
EP-0114270-B1 ACYL DERIVATIVES OF 1,4:3,6-DIANHYDRO-HEXITOLES, METHOD FOR THEIR PREPARATION AND THEIR PHARMAZEUTICAL USE Heinrich Mack Nachf. (DE) 1987-04-01 EP claimed
US-4559351-A Dihydropyridine derivatives of 1,4:3,6-dianhydrohexitols HEINRICH MACK NACHF. (DE) 1985-12-17 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260092174-A1 COMPOSITION FOR FORMING ECO-FRIENDLY POLYURETHANE FOAM HAVING IMPROVED INSULATION PROPERTIES AND METHOD FOR PREPARING POLYURETHANE FOAM PUF60, OGG1, PFAS THRB 3548/4885LMNA 2239/4885MAPT 3691/4885
US-20260098118-A1 Non-Softening Thermoplastic Polyurethanes PUF60, DCLRE1A, LRBA THRB 549/4885LMNA 2176/4885MAPT 2476/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.