Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.47 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.56 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.56 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.56 |
| ▸ | GGPS1 | O95749 | 4/20 | 0.53 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.49 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.49 |
| ▸ | FDPS | P14324 | 4/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948533 | 0.93 | GRIK1 (0.54) | S1PR2S1PR1S1PR3S1PR5GGPS1 | |
| SCHEMBL6950336 | 0.93 | GRIK1 (0.54) | S1PR2S1PR1S1PR3S1PR5GGPS1 | |
| SCHEMBL6942845 | 0.93 | GRIK1 (0.54) | S1PR2S1PR1S1PR3S1PR5GGPS1 | |
| Phosphoric Acid SCHEMBL28195519 | 0.88 | GRIK1 (0.59) | GRIK1GRIK2FDPSSLC1A2SLC1A1 | |
| Phosphoric Acid SCHEMBL28196208 | 0.86 | CA2 (0.61) | GRIK1GRIK2FDPSSLC1A2SLC1A1 | |
| Phosphoric Acid SCHEMBL18797445 | 0.86 | GRIK1 (0.58) | GRIK1GRIK2FDPSSLC1A2SLC1A1 | |
| SCHEMBL6942588 | 0.84 | EPHX2 (0.51) | GRIK1GRIK2FFAR1MAPTPPARD | |
| SCHEMBL6945273 | 0.84 | EPHX2 (0.51) | GRIK1GRIK2FFAR1MAPTPPARD | |
| SCHEMBL17511725 | 0.83 | DNM1 (0.56) | GRIK1GRIK2SLC1A2SLC1A1CA2 | |
| Phosphoric Acid SCHEMBL31190165 | 0.82 | S1PR2 (0.77) | S1PR2S1PR1S1PR3S1PR5GGPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2128708-B1 | Amine Phosphate Containing Photogenerating Layer Photoconductors | XEROX CORP (US) | 2011-09-07 | — | — | EP | claimed |