Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.42 |
| ▸ | CDK7 | P50613 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16040266 | 0.78 | ALDH1A1 (0.60) | ALDH1A1MAPTKDM4ECHRM1HDAC3 | |
| SCHEMBL10665554 | 0.75 | CYP2D6 (0.42) | HPGDALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL8262963 | 0.74 | FGFR1 (0.51) | HPGDALDH1A1HSD17B10L3MBTL1MAPT | |
| SCHEMBL1920689 | 0.73 | ALDH1A1 (0.50) | ALDH1A1MAPTKDM4ECHRM1HDAC3 | |
| SCHEMBL2446340 | 0.70 | SMN1; SMN2 (0.41) | ALDH1A1HSD17B10MAPTKDM4ECHRM1 | |
| SCHEMBL2017763 | 0.70 | CHRM1 (0.82) | ALDH1A1MAPTKDM4ECHRM1 | |
| SCHEMBL521863 | 0.69 | KDM4E (0.79) | HPGDALDH1A1HSD17B10L3MBTL1MAPT | |
| SCHEMBL1646037 | 0.69 | AURKA (0.49) | HPGDALDH1A1HSD17B10KDM4EHDAC3 | |
| SCHEMBL28005156 | 0.69 | MAPT (0.62) | ALDH1A1L3MBTL1MAPTKDM4ECHRM1 | |
| SCHEMBL11037651 | 0.69 | PARP1 (0.52) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2575785-A1 | ORAL DOSAGE FORMS OF BENDAMUSTINE AND THERAPEUTIC USE THEREOF | Astellas Deutschland GmbH (DE) | 2013-04-10 | — | — | EP | disclosed |
| EP-2575784-A1 | ORAL DOSAGE FORMS OF BENDAMUSTINE | Astellas Deutschland GmbH (DE) | 2013-04-10 | — | — | EP | disclosed |
| EP-2367542-A1 | ORAL DOSAGE FORMS OF BENDAMUSTINE | Astellas Deutschland GmbH (DE) | 2011-09-28 | — | — | EP | disclosed |
| EP-2367538-A2 | SOLID DOSAGE FORMS OF BENDAMUSTINE | Astellas Deutschland GmbH (DE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010063476-A2 | SOLID DOSAGE FORMS OF BENDAMUSTINE | ASTELLAS DEUTSCHLAND GMBH (DE) | 2010-06-10 | — | — | WO | disclosed |
| WO-2010063493-A1 | ORAL DOSAGE FORMS OF BENDAMUSTINE | ASTELLAS DEUTSCHLAND GMBH (DE) | 2010-06-10 | — | — | WO | disclosed |