Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15436004 | 0.72 | ALDH1A1 (0.44) | NPC1RAB9AALDH1A1MAPTKDM4E | |
| SCHEMBL2448392 | 0.71 | ALDH1A1 (0.43) | ALDH1A1MAPTEGFRTGFBR1KDM4E | |
| SCHEMBL1920686 | 0.70 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1MAPTTGFBR1KDM4E | |
| SCHEMBL2446345 | 0.70 | HPGD (0.48) | ALDH1A1MAPTDRD2DRD4DRD3 | |
| SCHEMBL2451575 | 0.67 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1MAPTTGFBR1KDM4E | |
| SCHEMBL3582641 | 0.67 | PARP1 (0.42) | SMN1; SMN2NPC1RAB9AALDH1A1PIK3CD | |
| SCHEMBL5515307 | 0.65 | AURKA (0.45) | IRAK4EGFRPIK3CDPIK3CB | |
| SCHEMBL27903856 | 0.65 | HTR6 (0.54) | ALDH1A1MAPTIRAK4PIK3CDPIK3CA | |
| SCHEMBL20120037 | 0.64 | GPR17 (0.41) | SMN1; SMN2ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL27860784 | 0.62 | MAPT (0.43) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2575784-A1 | ORAL DOSAGE FORMS OF BENDAMUSTINE | Astellas Deutschland GmbH (DE) | 2013-04-10 | — | — | EP | disclosed |
| EP-2575785-A1 | ORAL DOSAGE FORMS OF BENDAMUSTINE AND THERAPEUTIC USE THEREOF | Astellas Deutschland GmbH (DE) | 2013-04-10 | — | — | EP | disclosed |
| EP-2367542-A1 | ORAL DOSAGE FORMS OF BENDAMUSTINE | Astellas Deutschland GmbH (DE) | 2011-09-28 | — | — | EP | disclosed |
| EP-2367538-A2 | SOLID DOSAGE FORMS OF BENDAMUSTINE | Astellas Deutschland GmbH (DE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010063493-A1 | ORAL DOSAGE FORMS OF BENDAMUSTINE | ASTELLAS DEUTSCHLAND GMBH (DE) | 2010-06-10 | — | — | WO | disclosed |
| WO-2010063476-A2 | SOLID DOSAGE FORMS OF BENDAMUSTINE | ASTELLAS DEUTSCHLAND GMBH (DE) | 2010-06-10 | — | — | WO | disclosed |