Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28289753 | 0.92 | CHRM1 (0.58) | MAPTALDH1A1KCNJ1LMNAPKM | |
| SCHEMBL9642123 | 0.88 | MAPT (0.78) | MAPTALDH1A1KCNJ1LMNAPKM | |
| SCHEMBL7033532 | 0.87 | MAPT (0.72) | MAPTALDH1A1KCNJ1LMNAPKM | |
| SCHEMBL28005154 | 0.84 | MAPT (0.55) | MAPTALDH1A1KCNJ1LMNAPKM | |
| SCHEMBL7608604 | 0.83 | KDM4E (0.67) | MAPTALDH1A1KCNJ1LMNAPKM | |
| SCHEMBL7867650 | 0.83 | PKM (0.67) | MAPTALDH1A1KCNJ1LMNAPKM | |
| SCHEMBL16197999 | 0.82 | MAPT (0.73) | MAPTALDH1A1KCNJ1LMNAPKM | |
| SCHEMBL783686 | 0.81 | KDM4E (0.64) | MAPTALDH1A1KCNJ1LMNAPKM | |
| SCHEMBL9721024 | 0.81 | KDM4E (0.64) | MAPTALDH1A1KCNJ1LMNAPKM | |
| SCHEMBL9720944 | 0.81 | KDM4E (0.64) | MAPTALDH1A1KCNJ1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104418806-B | A kind of Preparation Method And Their Intermediate of hydrochloric acid N- demethyl bendamustine | 上海龙翔生物医药开发有限公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-104418806-A | Preparation method of hydrochloric acid N-demethylated bendamustine and intermediate of hydrochloric acid N-demethylated bendamustine | KNOWSHINE SHANGHAI PHARMACHEMICALS INC | 2015-03-18 | — | — | CN | disclosed |