Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR2 | O43603 | 9/20 | 0.44 |
| ▸ | GALR1 | P47211 | 6/20 | 0.42 |
| ▸ | POLA1 | P09884 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24862370 | 0.80 | POLA1 (0.47) | POLA1MAPTPOLBROCK2GAA | |
| SCHEMBL10143395 | 0.74 | GALR2 (0.64) | GALR2GALR1MAPTNPSR1LMNA | |
| SCHEMBL10144177 | 0.72 | GALR2 (0.82) | GALR2GALR1MAPTPOLBGAA | |
| SCHEMBL15639408 | 0.72 | ROCK2 (0.66) | ROCK2PIK3CA | |
| SCHEMBL21573639 | 0.71 | CYP1A2 (0.48) | POLA1MAPTPOLBNPSR1ROCK2 | |
| SCHEMBL20783969 | 0.70 | ROCK2 (0.64) | ROCK2 | |
| SCHEMBL20783917 | 0.70 | ROCK2 (0.63) | ROCK2 | |
| SCHEMBL21573654 | 0.70 | ROCK2 (0.60) | ROCK2 | |
| SCHEMBL21573627 | 0.69 | ROCK1 (0.44) | ROCK2 | |
| SCHEMBL17673536 | 0.67 | LMNA (0.61) | MAPTPOLBNPSR1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4116293-A2 | RHO KINASE INHIBITORS | Kadmon Corporation, LLC (US) | 2023-01-11 | — | — | EP | disclosed |
| EP-2903618-B1 | RHO KINASE INHIBITORS | KADMON CORP LLC (US) | 2022-06-01 | — | — | EP | disclosed |