Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | MST1R | Q04912 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2446680 | 0.84 | MET (0.67) | METKCNH2MST1R | |
| SCHEMBL2446683 | 0.79 | MET (0.64) | METKCNH2MST1R | |
| SCHEMBL2452747 | 0.79 | MET (0.69) | METKCNH2MST1R | |
| SCHEMBL2449019 | 0.79 | MET (0.67) | METKCNH2MST1R | |
| SCHEMBL4322496 | 0.77 | MET (0.55) | METKCNH2MST1R | |
| SCHEMBL2451612 | 0.77 | MET (0.59) | METKCNH2MST1R | |
| SCHEMBL2454487 | 0.76 | MET (0.67) | METKCNH2MST1R | |
| SCHEMBL2449222 | 0.75 | MET (0.72) | METKCNH2MST1R | |
| SCHEMBL3951023 | 0.75 | MET (0.76) | METKCNH2MST1R | |
| SCHEMBL2447718 | 0.73 | MET (0.68) | METKCNH2MST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896421-B1 | BENZOCYCLOHEPTAPYRIDINES AS INHIBITORS OF THE RECEPTOR TYROSINE KINASE MET | MERCK SHARP & DOHME (US) | 2011-09-14 | — | — | EP | disclosed |