Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.32 |
| ▸ | PRNP | P04156 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14438026 | 0.72 | MAOA (0.39) | PDPK1MMP12BRD4LRRK2ALDH1A1 | |
| SCHEMBL2913910 | 0.70 | PDPK1 (0.44) | PDPK1MMP12QPCTQPCTLABL1 | |
| SCHEMBL18237587 | 0.69 | LRRK2 (0.33) | PDPK1MMP12BRD4LRRK2ALDH1A1 | |
| SCHEMBL13217492 | 0.68 | DYRK1A (0.48) | PDPK1ALDH1A1SMN1; SMN2ADORA3CYP3A4 | |
| SCHEMBL402483 | 0.68 | PI4KA (0.45) | PDPK1LRRK2RAD52ALDH1A1KDM4E | |
| SCHEMBL1154855 | 0.68 | PARP1 (0.35) | PDPK1QPCTQPCTLRAD52ALDH1A1 | |
| SCHEMBL30568593 | 0.68 | DYRK1A (0.48) | PDPK1ALDH1A1SMN1; SMN2ADORA3CYP3A4 | |
| SCHEMBL9984011 | 0.68 | HPGD (0.38) | PDPK1MMP12HPGD | |
| SCHEMBL3082549 | 0.68 | ABL1 (0.54) | MMP12BRD4ABL1RAD52RIN1 | |
| SCHEMBL986616 | 0.68 | DRD1 (0.47) | PDPK1MMP12BRD4LRRK2QPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110218197-A1 | SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218197-A1 | SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS | TRPM8, TRPV1, TRPA1 | PDPK1 1714/4885MMP12 2217/4885BRD4 577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.