Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.63 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2451467 | 0.83 | TSHR (0.56) | NOTUMPBKLMNALRRK2KMT2A | |
| SCHEMBL9984155 | 0.82 | GAA (0.52) | NOTUMPBKLMNAKMT2AMEN1 | |
| SCHEMBL2558933 | 0.82 | PBK (0.49) | NOTUMPBKLMNALRRK2KMT2A | |
| SCHEMBL13419316 | 0.81 | PBK (0.46) | NOTUMPBKLMNAKMT2AMEN1 | |
| SCHEMBL3416577 | 0.80 | HTR1A (0.50) | PBKHTR1AHTR7ALDH1A1TSHR | |
| SCHEMBL612539 | 0.79 | EPHX2 (0.57) | NOTUMLMNAKMT2AALDH1A1TSHR | |
| SCHEMBL2558977 | 0.79 | ALDH1A1 (0.60) | NOTUMPBKALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2446475 | 0.79 | KMT2A (0.62) | NOTUMPBKLMNALRRK2KMT2A | |
| SCHEMBL14125452 | 0.78 | NOTUM (1.00) | NOTUMKDM4EALOX15 | |
| SCHEMBL9984703 | 0.77 | ALDH1A1 (0.56) | LMNAKMT2APOLBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-09-07 | — | — | EP | disclosed |