⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447439 | 1.00 | — | — | |
| SCHEMBL9664191 | 0.72 | — | — | |
| SCHEMBL27625706 | 0.68 | KCNH2 (0.33) | — | |
| SCHEMBL28795096 | 0.67 | — | — | |
| SCHEMBL10064756 | 0.66 | TSHR (0.32) | — | |
| SCHEMBL14587942 | 0.65 | — | — | |
| SCHEMBL27646113 | 0.65 | ALDH1A1 (0.41) | — | |
| SCHEMBL3883315 | 0.65 | CTSK (0.31) | — | |
| SCHEMBL702976 | 0.65 | — | — | |
| SCHEMBL3554767 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1240137-B1 | METHOD FOR MAKING 24(S)-HYDROXYVITAMIN D 2 | BONE CARE INT INC (US) | 2004-06-09 | — | — | EP | claimed |
| EP-1240137-A1 | METHOD FOR MAKING 24(S)-HYDROXYVITAMIN D 2 | BONE CARE INTERNATIONAL, INC. (US) | 2002-09-18 | — | — | EP | claimed |
| US-6359012-B1 | COUPLING 2,3-DIMETHYL-2-TRIETHYLSILYLOXYBUTYRALDEHYDE AND A C-22 VITAMIN D PHOSPHINE OXIDE DERIVATIVE TO FORM A 3,24-DIPROTECTED TRANS-VITAMIN D2; DEPROTECTING AND ISOMERIZING | BONE CARE INTERNATIONAL, INC. | 2002-03-19 | — | — | US | claimed |
| WO-2001046131-A1 | METHOD FOR MAKING 24(S)-HYDROXYVITAMIN D¿2? | BONE CARE INTERNATIONAL, INC. (US) | 2001-06-28 | — | — | WO | claimed |
| US-9833490-B1 | Drug combination for the treatment of infertility and its preparation methods and applications | SICHUAN SHANZE BIOTECH., LTD. (CN) | 2017-12-05 | — | — | US | disclosed |
| US-8026379-B2 | Paricalcitol intermediates | FORMOSA LABORATORIES, INC. (TW) | 2011-09-27 | — | — | US | disclosed |
| US-20090318722-A1 | PROCESS FOR PREPARATION OF PARICALCITOL INTERMEDIATES | FORMOSA LABORATORIES INC. (TW) | 2009-12-24 | — | — | US | disclosed |
| EP-1240137-B1 | METHOD FOR MAKING 24(S)-HYDROXYVITAMIN D 2 | BONE CARE INT INC (US) | 2004-06-09 | — | — | EP | disclosed |
| EP-1240137-A1 | METHOD FOR MAKING 24(S)-HYDROXYVITAMIN D 2 | BONE CARE INTERNATIONAL, INC. (US) | 2002-09-18 | — | — | EP | disclosed |
| US-6359012-B1 | COUPLING 2,3-DIMETHYL-2-TRIETHYLSILYLOXYBUTYRALDEHYDE AND A C-22 VITAMIN D PHOSPHINE OXIDE DERIVATIVE TO FORM A 3,24-DIPROTECTED TRANS-VITAMIN D2; DEPROTECTING AND ISOMERIZING | BONE CARE INTERNATIONAL, INC. | 2002-03-19 | — | — | US | disclosed |
| WO-2001046131-A1 | METHOD FOR MAKING 24(S)-HYDROXYVITAMIN D¿2? | BONE CARE INTERNATIONAL, INC. (US) | 2001-06-28 | — | — | WO | disclosed |