Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL480890 | 0.96 | ABL1 (0.46) | ABL1TRPA1CLK1MAPTPI4KB | |
| SCHEMBL4408309 | 0.95 | ABL1 (0.45) | ABL1TRPA1CLK1MAPTPI4KB | |
| SCHEMBL2445209 | 0.93 | FFAR4 (0.50) | ABL1TRPA1FFAR4MEN1NPC1 | |
| SCHEMBL2445205 | 0.90 | FFAR4 (0.47) | ABL1TRPA1FFAR4MEN1NPC1 | |
| SCHEMBL481106 | 0.88 | TRPA1 (0.45) | TRPA1FFAR4MEN1NPC1RAB9A | |
| SCHEMBL2443035 | 0.85 | MAPT (0.49) | ABL1TRPA1CLK1MAPTPI4KB | |
| SCHEMBL480419 | 0.84 | FFAR4 (0.48) | TRPA1FFAR4MEN1NPC1RAB9A | |
| SCHEMBL2450413 | 0.83 | ABL1 (0.51) | ABL1TRPA1CLK1MAPTMEN1 | |
| SCHEMBL2450859 | 0.83 | TRPA1 (0.48) | ABL1TRPA1CLK1MAPTPI4KB | |
| SCHEMBL480411 | 0.82 | TRPA1 (0.58) | ABL1TRPA1CLK1MAPTPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114184-A1 | AMIDES OF HETEROCYCLIC COMPOUNDS AS TRPA1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114184-A1 | AMIDES OF HETEROCYCLIC COMPOUNDS AS TRPA1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-09-22 | — | — | WO | disclosed |