Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 4/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 13/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29762067 | 0.86 | PDK1 (0.54) | PDK1HRH3DRD4DRD3 | |
| SCHEMBL10263231 | 0.84 | PDK1 (0.53) | PDK1HRH3DRD4 | |
| SCHEMBL24037258 | 0.84 | PDK1 (0.53) | PDK1HRH3DRD4 | |
| SCHEMBL26280856 | 0.83 | PDK1 (0.51) | PDK1HRH3DRD4 | |
| SCHEMBL23560021 | 0.83 | PDK1 (0.54) | PDK1HRH3DRD4 | |
| SCHEMBL26280853 | 0.83 | PDK1 (0.51) | PDK1HRH3DRD4 | |
| SCHEMBL26370089 | 0.82 | ALDH1A1 (0.54) | PDK1HRH3DRD4 | |
| SCHEMBL23560447 | 0.81 | PDK1 (0.49) | PDK1HRH3DRD4 | |
| SCHEMBL26621715 | 0.81 | PDK1 (0.49) | PDK1HRH3DRD4 | |
| SCHEMBL15727444 | 0.80 | PDK1 (0.58) | PDK1HRH3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220169660-A1 | CYCLIC AMINO-PYRAZINECARBOXAMIDE COMPOUNDS AND USES THEREOF | SILVERBACK THERAPEUTICS INC (US) | 2022-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220169660-A1 | CYCLIC AMINO-PYRAZINECARBOXAMIDE COMPOUNDS AND USES THEREOF | TGFBR2, ACVR2A, SMAD2 | PDK1 875/4885HRH3 422/4885DRD4 4877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.