Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 5/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24477291 | 0.92 | TYK2 (0.42) | TYK2ALDH1A1KDM4EHPGDPDE2A | |
| SCHEMBL24477304 | 0.86 | ALDH1A1 (0.59) | ALDH1A1KDM4EHPGDPDE2AHSD17B10 | |
| SCHEMBL24477483 | 0.80 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDHSD11B1HSD17B10 | |
| SCHEMBL24477303 | 0.78 | ALDH1A1 (0.56) | ALDH1A1KDM4EHPGDPDE2ALMNA | |
| SCHEMBL24477484 | 0.75 | KDM4E (0.49) | TYK2ALDH1A1KDM4EHPGDPDE2A | |
| SCHEMBL24477307 | 0.74 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL20016113 | 0.74 | PDE2A (0.55) | TYK2ALDH1A1KDM4EHPGDPDE2A | |
| SCHEMBL12943694 | 0.73 | TYK2 (0.52) | TYK2ALDH1A1KDM4EHPGDPDE2A | |
| SCHEMBL24477486 | 0.72 | GSK3A (0.48) | ALDH1A1KDM4EHPGDHSD11B1LMNA | |
| SCHEMBL19560173 | 0.72 | TYK2 (0.51) | TYK2ALDH1A1KDM4EHPGDPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220169652-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | LYSOSOMAL THERAPEUTICS INC. | 2022-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220169652-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | PARK7, PNP, GAA | TYK2 1719/4885ALDH1A1 1213/4885KDM4E 899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.