Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.43 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.43 |
| ▸ | UBE2I | P63279 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24477290 | 0.90 | ADORA3 (0.50) | KDM4EALDH1A1HPGDADORA2AADORA3 | |
| SCHEMBL24477300 | 0.84 | ALDH1A1 (0.72) | KDM4EALDH1A1HPGDADORA2AADORA3 | |
| SCHEMBL24477485 | 0.80 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDADORA2AADORA3 | |
| SCHEMBL22472792 | 0.79 | ADORA2A (0.42) | KDM4EALDH1A1HPGDADORA2AADORA3 | |
| SCHEMBL20016113 | 0.76 | PDE2A (0.55) | KDM4EALDH1A1HPGDMAPTHKDC1 | |
| SCHEMBL24477481 | 0.75 | TYK2 (0.42) | KDM4EALDH1A1HPGDMAPTHKDC1 | |
| SCHEMBL12943694 | 0.75 | TYK2 (0.52) | KDM4EALDH1A1HPGDMAPTHKDC1 | |
| SCHEMBL24477299 | 0.74 | ALDH1A1 (0.71) | KDM4EALDH1A1HPGDADORA2AADORA3 | |
| SCHEMBL19560173 | 0.74 | TYK2 (0.51) | KDM4EALDH1A1HPGDMAPTHKDC1 | |
| SCHEMBL22767517 | 0.73 | HSD11B1 (0.42) | KDM4EALDH1A1HPGDMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220169652-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | LYSOSOMAL THERAPEUTICS INC. | 2022-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220169652-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | PARK7, PNP, GAA | KDM4E 899/4885ALDH1A1 1213/4885HPGD 1396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.