Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 2/20 | 0.60 |
| ▸ | CDK1 | P06493 | 2/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.60 |
| ▸ | GSK3A | P49840 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.60 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.60 |
| ▸ | BRD4 | O60885 | 7/20 | 0.50 |
| ▸ | CDK9 | P50750 | 3/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4929127 | 0.79 | PTK6 (0.49) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL4925395 | 0.79 | CCNB2 (0.54) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL31240595 | 0.78 | CDK1 (0.49) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL2444894 | 0.77 | CCNB2 (0.64) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL14115561 | 0.76 | CCNB2 (0.54) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL490606 | 0.76 | CCNB2 (1.00) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL5538584 | 0.75 | CDK9 (0.40) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL4929965 | 0.75 | CCNB2 (0.50) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL16041244 | 0.75 | CDC7 (0.59) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL31240848 | 0.75 | CDC7 (0.59) | CCNB2CDK1CCNB1CCNB3CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859581-B2 | Azaheterocyclic compounds as kinase inhibitors | MERCK PATENT GMBH (DE) | 2014-10-14 | — | — | US | disclosed |
| EP-1874769-B1 | NOVEL AZA- HETEROCYCLES SERVING AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2011-09-14 | — | — | EP | disclosed |
| US-20080176892-A1 | Anticancer agents; synergistic use; regulate and/or modulate tyrosine kinase signal transduction particularly an IGF-R1-inhibiting action; 3-[2-(3,4,5-trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-4-ylamino]benzonitrile; reaction with arylsilylacetylene | MERCK PATENT GMBH (DE) | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176892-A1 | Anticancer agents; synergistic use; regulate and/or modulate tyrosine kinase signal transduction particularly an IGF-R1-inhibiting action; 3-[2-(3,4,5-trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-4-ylamino]benzonitrile; reaction with arylsilylacetylene | IGF1R, IGFBP1, ERBB2 | CCNB2 693/4885CDK1 99/4885CCNB1 562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.