Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 9/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779702 | 0.77 | MAP3K14 (0.52) | CDK9CCNT1DYRK1BGSK3AGSK3B | |
| SCHEMBL2990264 | 0.76 | EGFR (0.38) | CDK9CDC7PIM1CCNT1BRD4 | |
| SCHEMBL2447762 | 0.75 | CCNB2 (0.60) | CDK9CDC7PIM1CCNT1BRD4 | |
| SCHEMBL24615544 | 0.71 | CDK9 (0.43) | CDK9CDC7PIM1CCNT1AXL | |
| SCHEMBL2444894 | 0.69 | CCNB2 (0.64) | CDK9CDC7PIM1CHUKMAPK14 | |
| SCHEMBL1748886 | 0.69 | IGF1R (0.67) | CDK9CDC7PIM1CCNT1DYRK1B | |
| SCHEMBL31240606 | 0.68 | EGFR (0.54) | CDK9CDC7PIM1CCNT1CHUK | |
| SCHEMBL1779401 | 0.68 | IGF1R (0.71) | CDK9CDC7PIM1CCNT1DYRK1B | |
| SCHEMBL3415638 | 0.68 | CDK9 (0.48) | CDK9CDC7PIM1CCNT1AXL | |
| SCHEMBL2984402 | 0.68 | IGF1R (0.51) | CDK9CDC7PIM1CCNT1CHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799691-A1 | NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2007-06-27 | — | — | EP | claimed |
| WO-2006037875-A1 | NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2006-04-13 | — | — | WO | claimed |