Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | LOX | P28300 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8658514 | 0.94 | PTGS2 (0.62) | PTGS2PTGS1MAOALOXKDM4E | |
| SCHEMBL937206 | 0.93 | PTGS2 (0.61) | PTGS2PTGS1MAOALOXKDM4E | |
| SCHEMBL29415408 | 0.93 | PTGS2 (0.61) | PTGS2PTGS1MAOALOXKDM4E | |
| Hydrochloric Acid SCHEMBL7352630 | 0.91 | PTGS2 (0.59) | PTGS2PTGS1MAOALOXKDM4E | |
| SCHEMBL4198455 | 0.85 | PTGS2 (0.62) | PTGS2PTGS1KDM4EALDH1A1RAB9A | |
| SCHEMBL7265178 | 0.83 | PTGS2 (0.50) | PTGS2MAOALOXKDM4EALDH1A1 | |
| SCHEMBL5711493 | 0.82 | PTGS2 (0.52) | PTGS2PTGS1ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL6801877 | 0.82 | PTGS2 (0.49) | PTGS2KDM4EALDH1A1RAB9A | |
| SCHEMBL6904881 | 0.82 | PTGS2 (0.68) | PTGS2PTGS1MAOALOXKDM4E | |
| SCHEMBL4884912 | 0.82 | PTGS2 (0.53) | PTGS2PTGS1MAOALOXL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575153-B2 | Pyridine-3-carboxyamide derivative | KOWA COMPANY, LTD. (JP) | 2013-11-05 | — | — | US | disclosed |
| EP-2380877-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | Kowa Company, Ltd. (JP) | 2011-10-26 | — | — | EP | disclosed |
| US-20110237590-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | KOWA COMPANY, LTD. (JP) | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237590-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | JAK3, JAK1, UACA | PTGS2 791/4885PTGS1 294/4885MAOA 2829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.