Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22709563 | 0.93 | KMT2A (0.39) | KMT2ANOTUMMAPTKDM1AMMP1 | |
| SCHEMBL24483073 | 0.92 | NOTUM (0.41) | KMT2ANOTUMMAPTMMP1MEN1 | |
| SCHEMBL22709565 | 0.88 | ALDH1A1 (0.40) | KMT2AMAPTMMP1KDM5AKDM4C | |
| SCHEMBL24483741 | 0.85 | SIGMAR1 (0.42) | KMT2AMAPTKDM1AMMP1KDM5A | |
| SCHEMBL22709350 | 0.85 | NOTUM (0.40) | KMT2ANOTUMMAPTMMP1MEN1 | |
| SCHEMBL30067231 | 0.84 | KMT2A (0.38) | KMT2AMAPTKDM1AMMP1KDM5A | |
| SCHEMBL22709564 | 0.83 | SIGMAR1 (0.41) | KMT2AMAPTMMP1KDM5AKDM4C | |
| SCHEMBL22709347 | 0.80 | HDAC9 (0.38) | NOTUMKDM1AMAPK1 | |
| SCHEMBL24483072 | 0.78 | SIGMAR1 (0.36) | KMT2AMAPTMMP1MEN1 | |
| SCHEMBL20137431 | 0.77 | KMT2A (0.47) | KMT2AMAPTKDM1AMMP1KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115439-A1 | KRAS G12C INHIBITORS AND USES THEREOF | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2022-06-02 | — | — | WO | disclosed |