Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.40 |
| ▸ | HTR1A | P08908 | 5/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 4/20 | 0.35 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 2/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2450284 | 0.88 | HTR6 (0.47) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL2446379 | 0.85 | HTR2C (0.52) | HTR6HTR2C | |
| SCHEMBL2448448 | 0.83 | HTR6 (0.50) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL2450688 | 0.81 | HTR6 (0.45) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL949296 | 0.80 | HTR6 (0.50) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL2448414 | 0.76 | HTR6 (0.44) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL4649415 | 0.72 | ROCK1 (0.46) | HTR6HTR1AHTR7DRD2HTR2A | |
| Tert-Butyl Formate SCHEMBL27986724 | 0.71 | HTR6 (0.44) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL4688099 | 0.70 | HTR6 (0.43) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL264556 | 0.69 | HTR2C (0.62) | HTR6DRD2HTR2ADRD3HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139880-B1 | QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR | ABBOTT GMBH & CO KG (DE) | 2011-09-14 | — | — | EP | claimed |