Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.60 |
| ▸ | HTR2A | P28223 | 5/20 | 0.51 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | HTR7 | P34969 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | HTR2B | P41595 | 3/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9902743 | 0.88 | HTR6 (0.50) | HTR6HTR2AHTR1AHTR7DRD2 | |
| SCHEMBL4690981 | 0.88 | HTR6 (0.61) | HTR6HTR2AHTR1AHTR7DRD2 | |
| SCHEMBL9902745 | 0.87 | HTR6 (0.66) | HTR6HTR2AHTR7DRD2HTR2B | |
| SCHEMBL9902830 | 0.86 | HTR6 (0.48) | HTR6HTR2AHTR1AHTR7DRD2 | |
| SCHEMBL17580927 | 0.85 | HTR6 (0.46) | HTR6HTR2AHTR1AHTR7DRD2 | |
| SCHEMBL17580617 | 0.83 | HTR6 (0.42) | HTR6HTR2ACHRM1 | |
| SCHEMBL17580675 | 0.83 | HTR6 (0.44) | HTR6HTR2AHTR1AHTR7DRD2 | |
| SCHEMBL9903085 | 0.81 | HTR6 (0.57) | HTR6HTR2AHTR1AHTR7DRD2 | |
| SCHEMBL17580720 | 0.81 | HTR6 (0.42) | HTR6HTR2AHTR1AHTR7DRD2 | |
| SCHEMBL17580888 | 0.81 | HTR6 (0.52) | HTR6HTR2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120950-B1 | USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN | GLAXO GROUP LTD (GB) | 2012-07-04 | — | — | EP | claimed |
| EP-1824830-B1 | RADIOLABELLED QUINOLINE-BASED LIGANDS FOR THE 5-HT6 RECEPTOR FUNCTIONALITY | GLAXO GROUP LTD (GB) | 2010-07-14 | — | — | EP | claimed |