Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 2/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | CPA1 | P15085 | 1/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL27814390 | 0.95 | SLC7A5 (0.57) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL1537436 | 0.95 | SLC7A5 (0.71) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL1537442 | 0.95 | SLC7A5 (0.71) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL14247975 | 0.95 | SLC7A5 (0.71) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL14562522 | 0.95 | SLC7A5 (0.71) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL29069495 | 0.92 | SLC7A5 (0.67) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL17294091 | 0.91 | SLC7A5 (0.65) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL10598020 | 0.89 | SLC7A5 (0.61) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL29198067 | 0.89 | SLC7A5 (0.61) | SLC7A5PTGS1ALPIPKMXIAP | |
| Tyrosine SCHEMBL7795418 | 0.88 | SLC7A5 (0.61) | SLC7A5PTGS1ALPIPKMXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013044105-A1 | NANOTUBES AND COMPOSITIONS THEREOF | BROWN UNIVERSITY (US) | 2013-03-28 | — | — | WO | disclosed |
| EP-2547373-A1 | NANOTUBES AND COMPOSITIONS THEREOF | Brown University (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011116085-A1 | NANOTUBES AND COMPOSITIONS THEREOF | BROWN UNIVERSITY (US) | 2011-09-22 | — | — | WO | disclosed |
| WO-2007146319-A9 | METHODS AND APPARATUS FOR USING POLYMER-BASED BEADS AND HYDROGELS FOR CARDIAC APPLICATIONS | SYMPHONY MEDICAL INC (US) | 2008-04-24 | — | — | WO | disclosed |
| WO-2007146319-A2 | METHODS AND APPARATUS FOR USING POLYMER-BASED BEADS AND HYDROGELS FOR CARDIAC APPLICATIONS | SYMPHONY MEDICAL, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| US-6927234-B2 | Xanthone derivatives, method of production thereof, and pharmaceutical composition containing the same | KUBOYAMA BIO KEN INC. (JP) | 2005-08-09 | — | — | US | disclosed |
| US-20050070590-A1 | Novel xanthone derivatives, method of production thereof, and pharmaceutical composition containing the same | KUBOYAMA BIO KEN INC. (JP) | 2005-03-31 | — | — | US | disclosed |
| EP-0278781-A2 | Peptides with laminin activity | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce (US) | 1988-08-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070590-A1 | Novel xanthone derivatives, method of production thereof, and pharmaceutical composition containing the same | SOX18, IL17A, HSD17B7 | ADORA3 4246/4885SLC7A5 4359/4885PTGS1 1490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.