SCHEMBL24489653

SCHEMBL24489653

C1=CCCC(c2nc(-c3ccccc3)nc(-n3c(-c4ccccc4)nc4cn5c(cc43)nc3ccccc35)n2)=C1

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.33
ESR2 Q92731 1/20 0.33
KDM4E B2RXH2 2/20 0.30
ALDH1A1 P00352 2/20 0.30
HPGD P15428 2/20 0.30
LMNA P02545 1/20 0.30
GLA P06280 1/20 0.30
GAA P10253 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21622698 0.86 ESR1 (0.42) ESR1ESR2KDM4EALDH1A1HPGD
SCHEMBL23917086 0.78 ESR1 (0.42) ESR1ESR2KDM4EALDH1A1HPGD
SCHEMBL23917375 0.74 ALDH1A1 (0.44) ESR1ESR2KDM4EALDH1A1HPGD
SCHEMBL22507391 0.73 VCP (0.39) ESR1ESR2KDM4EALDH1A1HPGD
SCHEMBL18904706 0.72 L3MBTL1 (0.42) KDM4EALDH1A1HPGDLMNAGLA
SCHEMBL15746080 0.71 ESR1 (0.58) ESR1ESR2KDM4EALDH1A1HPGD
SCHEMBL27456903 0.70 L3MBTL1 (0.40) KDM4EALDH1A1HPGDLMNAGLA
SCHEMBL19636294 0.69 KDM4E (0.38) KDM4EL3MBTL1
SCHEMBL21622705 0.69 ALK (0.37) KDM4EALDH1A1HPGDLMNAGLA
SCHEMBL24727190 0.69 L3MBTL1 (0.58) HPGDLMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3820966-B1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2022-06-08 EP disclosed