Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 2/20 | 0.61 |
| ▸ | PTPRC | P08575 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8979627 | 0.85 | S100A4 (0.61) | S100A4PTPRCMAPTKMT2ARECQL | |
| SCHEMBL5157698 | 0.77 | S100A4 (0.56) | S100A4PTPRCMAPTKMT2ARECQL | |
| SCHEMBL9257330 | 0.76 | S100A4 (0.77) | S100A4PTPRCMAPTKMT2ARECQL | |
| SCHEMBL28651375 | 0.76 | S100A4 (0.92) | S100A4PTPRCMAPTKMT2ARECQL | |
| SCHEMBL2347136 | 0.76 | S100A4 (0.84) | S100A4PTPRCMAPTKMT2ARECQL | |
| SCHEMBL2599501 | 0.76 | S100A4 (1.00) | S100A4PTPRCMAPTKMT2ARECQL | |
| SCHEMBL3039191 | 0.75 | TDP1 (0.67) | S100A4PTPRCMAPTKMT2ARECQL | |
| SCHEMBL1303600 | 0.75 | S100A4 (0.81) | S100A4PTPRCMAPTKMT2ARECQL | |
| SCHEMBL11317413 | 0.73 | S100A4 (0.78) | S100A4PTPRCMAPTKMT2ARECQL | |
| SCHEMBL1559811 | 0.72 | S100A4 (0.75) | S100A4PTPRCMAPTKMT2ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 751 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11807634-B2 | Cyclopropyl dihydroquinoline sulfonamide compounds | AMGEN INC. (US) | 2023-11-07 | — | — | US | disclosed |
| US-20230234948-A1 | CYCLOPROPYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2023-07-27 | — | — | US | disclosed |
| US-20230227442-A1 | HETEROALKYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2023-07-20 | — | — | US | disclosed |
| EP-3897855-B1 | KIF18A INHIBITORS | AMGEN INC (US) | 2023-06-07 | — | — | EP | disclosed |
| EP-4165024-A1 | CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | Amgen Inc. (US) | 2023-04-19 | — | — | EP | disclosed |
| EP-4165032-A1 | HETEROALKYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | Amgen Inc. (US) | 2023-04-19 | — | — | EP | disclosed |
| EP-4164748-A1 | CYCLOPROPYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | Amgen Inc. (US) | 2023-04-19 | — | — | EP | disclosed |
| CN-115697971-A | Cyclobutyldihydroquinoline sulfonamide compound | 美国安进公司 | 2023-02-03 | — | — | CN | disclosed |
| US-20220306604-A1 | CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2022-09-29 | — | — | US | disclosed |
| EP-4007753-A1 | KIF18A INHIBITORS | Amgen Inc. (US) | 2022-06-08 | — | — | EP | disclosed |
| WO-1996022275-A1 | METHOD OF PREPARING RETROVIRAL PROTEASE INHIBITOR INTERMEDIATES | G.D. SEARLE & CO. (US) | 1996-07-25 | — | — | WO | disclosed |
| EP-0715618-A1 | HYDROXYETHYLAMINO SULPHONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-06-12 | — | — | EP | disclosed |
| EP-0656887-A1 | HYDROXYETHYLAMINO SULFONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1995-06-14 | — | — | EP | disclosed |
| WO-1995014653-A1 | METHOD FOR MAKING INTERMEDIATES USEFUL IN SYNTHESIS OF RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1995-06-01 | — | — | WO | disclosed |
| EP-0641333-A1 | METHOD FOR MAKING INTERMEDIATES USEFUL IN SYNTHESIS OF RETROVIRAL PROTEASE INHIBITORS. | SEARLE & CO (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1995006061-A1 | RETROVIRAL PROTEASE INHIBITORS AND COMBINATIONS THEREOF | G.D. SEARLE & CO. (US) | 1995-03-02 | — | — | WO | disclosed |
| WO-1995006030-A1 | HYDROXYETHYLAMINO SULPHONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1995-03-02 | — | — | WO | disclosed |
| WO-1994004492-A1 | HYDROXYETHYLAMINO SULFONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1994-03-03 | — | — | WO | disclosed |
| WO-1993023388-A1 | METHOD FOR MAKING INTERMEDIATES USEFUL IN SYNTHESIS OF RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1993-11-25 | — | — | WO | disclosed |
| EP-0301477-A2 | Silver halide color photosensitive material and method of processing thereof | Fuji Photo Film Co., Ltd. (JP) | 1989-02-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227442-A1 | HETEROALKYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | SCN7A, TRPV1, SCNN1A | S100A4 1958/4885PTPRC 2378/4885MAPT 3487/4885 |
| US-20230234948-A1 | CYCLOPROPYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | TRPV1, SCN7A, TRPA1 | S100A4 2191/4885PTPRC 2803/4885MAPT 1731/4885 |
| US-11807634-B2 | Cyclopropyl dihydroquinoline sulfonamide compounds | TRPV1, SCN7A, TRPA1 | S100A4 2631/4885PTPRC 2923/4885MAPT 1751/4885 |
| US-20220306604-A1 | CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | TRPV1, SCN7A, TRPA1 | S100A4 2451/4885PTPRC 3734/4885MAPT 1589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.