Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | LOX | P28300 | 2/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24493583 | 0.89 | HRH3 (0.40) | HRH3APAF1CASP3SENP8SENP7 | |
| SCHEMBL30578250 | 0.86 | LOXL2 (0.51) | HRH3CXCR1MAOAMAOBLOX | |
| SCHEMBL429671 | 0.86 | LOXL2 (0.51) | HRH3CXCR1MAOAMAOBLOX | |
| SCHEMBL427054 | 0.79 | HRH3 (0.44) | HRH3CXCR1EGFRMAOAMAOB | |
| SCHEMBL27095942 | 0.78 | APAF1 (0.37) | HRH3APAF1CASP3SENP8SENP7 | |
| SCHEMBL24493350 | 0.78 | APAF1 (0.41) | HRH3APAF1CASP3SENP8SENP7 | |
| SCHEMBL24493315 | 0.78 | MRGPRX1 (0.47) | ROCK2ROCK1 | |
| SCHEMBL30578229 | 0.78 | APAF1 (0.41) | HRH3APAF1CASP3SENP8SENP7 | |
| SCHEMBL30578216 | 0.78 | MRGPRX1 (0.47) | ROCK2ROCK1 | |
| SCHEMBL448816 | 0.78 | EGFR (0.40) | HRH3CXCR1LRRK2EGFRACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022118016-A2 | ENZYME INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2022-06-09 | — | — | WO | disclosed |