Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24495181 | 0.87 | TSHR (0.46) | MEN1KMT2AL3MBTL1MTNR1AMTNR1B | |
| SCHEMBL24495113 | 0.87 | L3MBTL1 (0.44) | MEN1KMT2AL3MBTL1MTNR1AMTNR1B | |
| SCHEMBL24495071 | 0.87 | L3MBTL1 (0.44) | MEN1KMT2AL3MBTL1MTNR1AMTNR1B | |
| SCHEMBL24495135 | 0.85 | L3MBTL1 (0.43) | MEN1KMT2AL3MBTL1MTNR1AMTNR1B | |
| SCHEMBL24495121 | 0.85 | NPY5R (0.49) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL24495280 | 0.85 | L3MBTL1 (0.45) | MEN1KMT2AL3MBTL1MTNR1AMTNR1B | |
| SCHEMBL24495295 | 0.84 | L3MBTL1 (0.42) | MEN1KMT2AL3MBTL1MTNR1AMTNR1B | |
| SCHEMBL17291618 | 0.83 | L3MBTL1 (0.46) | MEN1KMT2AL3MBTL1MTNR1AMTNR1B | |
| SCHEMBL15571219 | 0.83 | L3MBTL1 (0.46) | MEN1KMT2AL3MBTL1MTNR1AMTNR1B | |
| SCHEMBL24495053 | 0.82 | L3MBTL1 (0.46) | MEN1KMT2AL3MBTL1MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12043602-B2 | Fendiline derivatives | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-07-23 | — | — | US | disclosed |
| US-12043602-B2 | Fendiline derivatives | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-07-23 | — | — | US | disclosed |
| US-12043602-B2 | Fendiline derivatives | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-07-23 | — | — | US | disclosed |
| US-20220177440-A1 | Fendiline Derivatives | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2022-06-09 | — | — | US | disclosed |
| US-20220177440-A1 | Fendiline Derivatives | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2022-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12043602-B2 | Fendiline derivatives | CYP11B2, CYP3A7, CYP4F2 | MEN1 3333/4885KMT2A 3225/4885L3MBTL1 4482/4885 |
| US-20220177440-A1 | Fendiline Derivatives | CYP11B2, CYP3A7, CYP4F2 | MEN1 3333/4885KMT2A 3225/4885L3MBTL1 4482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.