Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.49 |
| ▸ | RAB9A | P51151 | 10/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 3/20 | 0.46 |
| ▸ | NR2E3 | Q9Y5X4 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2379539 | 0.99 | SAE1 (0.55) | SAE1KDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2450558 | 0.85 | NPC1 (0.56) | KDM4ERAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL2449273 | 0.83 | ROCK2 (0.41) | SAE1KDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2380592 | 0.83 | ROCK2 (0.53) | RAB9ASMN1; SMN2ALDH1A1NPC1MEN1 | |
| SCHEMBL2449265 | 0.83 | ATP4A (0.53) | KDM4EMEN1KMT2AMAPK1MAPT | |
| SCHEMBL2380469 | 0.83 | ROCK2 (0.45) | RAB9ASMN1; SMN2ALDH1A1NPC1MEN1 | |
| Bromide SCHEMBL5621757 | 0.83 | ROCK2 (0.41) | SAE1KDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| Bromide SCHEMBL2379076 | 0.83 | ATP4A (0.55) | KDM4EMEN1KMT2AMAPK1MAPT | |
| SCHEMBL2444356 | 0.82 | KMT2A (0.43) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL2443677 | 0.82 | NPC1 (0.54) | RAB9AALDH1A1NPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716127-B1 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND (DE) | 2014-08-06 | — | — | EP | disclosed |
| EP-2380885-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2366392-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |
| EP-2366697-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |