Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | ATP4A | P20648 | 1/20 | 0.42 |
| ▸ | ATP4B | P51164 | 1/20 | 0.42 |
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | C1S | P09871 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2379900 | 0.99 | ATP4A (0.43) | KMT2AMEN1ROCK2ROCK1ATP4A | |
| SCHEMBL2449265 | 0.88 | ATP4A (0.53) | KMT2AMEN1ROCK2ROCK1ATP4A | |
| Bromide SCHEMBL2379076 | 0.87 | ATP4A (0.55) | KMT2AMEN1ROCK2ROCK1ATP4A | |
| SCHEMBL2379701 | 0.85 | KMT2A (0.46) | KMT2AMEN1ROCK2ROCK1ATP4A | |
| SCHEMBL2380570 | 0.85 | GSTO1 (0.48) | KMT2AMEN1ROCK2ROCK1ATP4A | |
| SCHEMBL2451042 | 0.84 | KMT2A (0.48) | KMT2AMEN1ROCK2ROCK1ATP4A | |
| SCHEMBL2380592 | 0.83 | ROCK2 (0.53) | KMT2AMEN1ROCK2ROCK1MAPT | |
| SCHEMBL2380469 | 0.83 | ROCK2 (0.45) | KMT2AMEN1ROCK2ROCK1ATP4A | |
| Bromide SCHEMBL2379936 | 0.83 | KMT2A (0.48) | KMT2AMEN1ROCK2ROCK1ATP4A | |
| SCHEMBL2449599 | 0.82 | SAE1 (0.55) | KMT2AMEN1ROCK2ROCK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716127-B1 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND (DE) | 2014-08-06 | — | — | EP | disclosed |
| EP-2380885-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2366392-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |
| EP-2366697-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |