SCHEMBL24496705

SCHEMBL24496705

CN1CC(C(=O)NO)Oc2ccccc21

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 2/20 0.45
HDAC7 Q8WUI4 2/20 0.45
HDAC5 Q9UQL6 2/20 0.45
SIRT1 Q96EB6 8/20 0.42
NISCH Q9Y2I1 1/20 0.42
HPGD P15428 3/20 0.41
ALDH1A1 P00352 2/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
SIRT2 Q8IXJ6 2/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
HDAC3 O15379 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29586755 1.00 HDAC4 (0.45) HDAC4HDAC7HDAC5SIRT1NISCH
SCHEMBL2685855 0.83 SIRT1 (0.58) SIRT1SIRT2
SCHEMBL31566197 0.83 SIRT1 (0.58) SIRT1SIRT2
SCHEMBL925260 0.83 SIRT1 (0.48) SIRT1NISCHHPGDALDH1A1SMN1; SMN2
SCHEMBL1689630 0.82 KMT2A (0.55) SIRT1NISCHHPGDALDH1A1SMN1; SMN2
SCHEMBL11544729 0.80 KMT2A (0.48) SIRT1HPGDALDH1A1SMN1; SMN2NPC1
Hydrochloric Acid SCHEMBL18581817 0.80 ALDH1A1 (0.41) SIRT1NISCHHPGDALDH1A1SMN1; SMN2
SCHEMBL18581860 0.80 KDM4E (0.39) HDAC4HDAC7HDAC5SIRT1NISCH
SCHEMBL22000892 0.77 ALDH1A1 (0.68) HPGDALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL7820037 0.75 POLB (0.53) SIRT1ALDH1A1SMN1; SMN2SIRT2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022120048-A1 HDAC INHIBITORS UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2022-06-09 WO disclosed