Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 19/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24497831 | 0.77 | HCRTR2 (0.48) | HCRTR2 | |
| SCHEMBL24823775 | 0.77 | ALDH1A1 (0.47) | HCRTR2ALDH1A1 | |
| SCHEMBL24497732 | 0.76 | ACACB (0.46) | HCRTR2 | |
| SCHEMBL19381000 | 0.75 | SLC18A3 (0.49) | HCRTR2 | |
| SCHEMBL26941799 | 0.75 | DRD2 (0.49) | HCRTR2 | |
| SCHEMBL8466348 | 0.75 | SLC18A3 (0.49) | HCRTR2 | |
| SCHEMBL24823466 | 0.74 | HCRTR2 (0.37) | HCRTR2 | |
| SCHEMBL10707465 | 0.73 | SLC18A3 (0.44) | HCRTR2 | |
| SCHEMBL10712857 | 0.73 | SLC18A3 (0.44) | HCRTR2 | |
| SCHEMBL18361625 | 0.72 | DRD2 (0.49) | HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022119888-A1 | 3-HETEROARYL PYRROLIDINE AND PIPERIDINE OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-09 | — | — | WO | disclosed |