SCHEMBL2449809

SCHEMBL2449809

Cc1c[nH]nc1-c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.48
ALDH1A1 P00352 6/20 0.42
KDM4E B2RXH2 5/20 0.42
HPGD P15428 4/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
MAPT P10636 2/20 0.42
GFER P55789 1/20 0.42
RAB9A P51151 3/20 0.41
POLB P06746 2/20 0.41
MEN1 O00255 1/20 0.41
PKM P14618 1/20 0.41
KMT2A Q03164 1/20 0.41
PDE10A Q9Y233 1/20 0.41
GAA P10253 3/20 0.41
MAPK10 P53779 2/20 0.41
ALPL P05186 1/20 0.41
IDO1 P14902 1/20 0.41
TTK P33981 1/20 0.41
AKT2 P31751 2/20 0.39
CHEK1 O14757 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11621636 0.84 DCUN1D1 (0.41) ALOX15ALDH1A1HPGDSMN1; SMN2RAB9A
SCHEMBL6850964 0.83 MEN1 (0.48) ALDH1A1KDM4EHPGDSMN1; SMN2MAPT
SCHEMBL15186271 0.81 LMNA (0.40) ALOX15ALDH1A1HPGDMAPTPOLB
SCHEMBL6850959 0.80 IDO1 (0.46) HPGDSMN1; SMN2RAB9AIDO1NPC1
SCHEMBL15741508 0.79 NPC1 (0.43) ALDH1A1KDM4ESMN1; SMN2MAPTRAB9A
SCHEMBL3755589 0.79 IKBKB (0.41) ALOX15KDM4EHPGDGFERGAA
SCHEMBL3160320 0.79 MAPK14 (0.42) ALDH1A1KDM4ESMN1; SMN2RAB9AMEN1
SCHEMBL13363877 0.79 ERBB2 (0.39) HPGDSMN1; SMN2MAPTRAB9AMEN1
SCHEMBL28158417 0.78 KCNH2 (0.33) LMNA
SCHEMBL5223142 0.78 MEN1 (0.53) ALDH1A1KDM4EHPGDMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0861237-A1 SUBSTITUTED 1-METHYL-3-PHENYLPYRAZOLES AND THE USE THEREOF AS HERBICIDES AND FOR THE DESICCATION OR DEFOLIATION OF PLANTS BASF AKTIENGESELLSCHAFT (DE) 1998-09-02 EP claimed
EP-0828779-A4 WATER-SOLUBLE POLYMERS AND COMPOSITIONS THEREOF UNIV CALIFORNIA (US) 1998-05-20 EP claimed
EP-0828779-A1 WATER-SOLUBLE POLYMERS AND COMPOSITIONS THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1998-03-18 EP claimed
WO-1997018195-A1 SUBSTITUTED 1-METHYL-3-PHENYLPYRAZOLES AND THE USE THEREOF AS HERBICIDES AND FOR THE DESICCATION OR DEFOLIATION OF PLANTS BASF AKTIENGESELLSCHAFT (DE) 1997-05-22 WO claimed
WO-1996038493-A1 WATER-SOLUBLE POLYMERS AND COMPOSITIONS THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1996-12-05 WO claimed
EP-4584259-A1 CK1ALPHA AND DUAL CK1ALPHA / GSPT1 DEGRADING COMPOUNDS Innovo Therapeutics, Inc. (US) 2025-07-16 EP disclosed
US-20240158370-A1 CK1 alpha AND DUAL CK1 alpha / GSPT1 DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. 2024-05-16 US disclosed
WO-2024054832-A1 CK1α AND DUAL CK1α / GSPT1 DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. (US) 2024-03-14 WO disclosed
WO-2023061294-A1 NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE REGULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 再鼎医药(上海)有限公司 2023-04-20 WO disclosed
EP-3885343-A1 INDOLE COMPOUNDS AS EZH2 INHIBITORS AND USES THEREOF Dana-Farber Cancer Institute, Inc. (US) 2021-09-29 EP disclosed
WO-2021124348-A1 MULTIPLE-COMPARTMENT DEVICE COMPRISING AT LEAST ONE INTERNAL FRANGIBLE SEAL CONTAINING A KERATIN FIBERS DYEING COMPOSITION L'ORéAL S.A. (FR) 2021-06-24 WO disclosed
EP-3110818-B1 9H-PYRIMIDO[4,5-B]INDOLES AND RELATED ANALOGS AS BET BROMODOMAIN INHIBITORS UNIV MICHIGAN REGENTS (US) 2019-10-23 EP disclosed
WO-1996002515-A1 HETEROCYCLIC- AND CARBOCYCLIC-SUBSTITUTED BENZOIC ACIDS AND SYNTHESIS THEREOF MONSANTO COMPANY (US) 1996-02-01 WO disclosed
EP-0515041-A2 Fungicidal pyrazoles, pyrazolines and tetrahydropyridazines E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-11-25 EP disclosed
WO-1992019615-A2 FUNGICIDAL PYRAZOLES, PYRAZOLINES AND TETRAHYDROPYRIDAZINES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-11-12 WO disclosed
CN-1066069-A Fungicidal pyrazoles, pyrazoline and tetrahydro pyridazine DU PONT (US) 1992-11-11 CN disclosed
EP-0389189-A2 Diazepine antiallergy agents Pfizer Limited (GB) 1990-09-26 EP disclosed
EP-0366329-A1 Halogeno-4-methylpyrazoles and process for preparing the same NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1990-05-02 EP disclosed
EP-0366328-A1 Process for preparing 4-methylpyrazoles NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1990-05-02 EP disclosed
US-4072498-A HERBICIDES THE UPJOHN COMPANY (US) 1978-02-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240158370-A1 CK1 alpha AND DUAL CK1 alpha / GSPT1 DEGRADING COMPOUNDS CKS1B, CKS2, MARK1 ALOX15 3260/4885ALDH1A1 1687/4885KDM4E 1794/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.