Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15741508 | 0.83 | NPC1 (0.43) | MEN1KMT2AMAPTERBB2SMN1; SMN2 | |
| SCHEMBL3755589 | 0.83 | IKBKB (0.41) | HPGDERBB2MAPK1DCUN1D1TDP1 | |
| SCHEMBL3160320 | 0.83 | MAPK14 (0.42) | MEN1KMT2AERBB2SMN1; SMN2ALDH1A1 | |
| SCHEMBL2449809 | 0.83 | ALOX15 (0.48) | MEN1KMT2AMAPTHPGDSMN1; SMN2 | |
| SCHEMBL5223142 | 0.82 | MEN1 (0.53) | MEN1KMT2AMAPTHPGDMAPK1 | |
| SCHEMBL15186271 | 0.81 | LMNA (0.40) | MAPTHPGDALDH1A1TDP1LMNA | |
| Hydrochloric Acid SCHEMBL30879670 | 0.80 | MEN1 (0.51) | MEN1KMT2AMAPTHPGDMAPK1 | |
| SCHEMBL14572024 | 0.80 | ERBB2 (0.46) | HPGDERBB2SMN1; SMN2TDP1LMNA | |
| SCHEMBL15236244 | 0.79 | MAP2K4 (0.33) | MEN1KMT2A | |
| SCHEMBL8806952 | 0.79 | MAP2K4 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947717-B2 | Inhibitors of lethal factor protease | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-05-24 | — | — | US | disclosed |
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | THE BURNHAM INSTITUTE (US) | 2010-01-21 | — | — | US | disclosed |
| US-20070049603-A1 | Raf inhibitor compounds and methods of use thereof | ARRAY BIOPHARMA INC. | 2007-03-01 | — | — | US | disclosed |
| CN-1154637-C | Method for producing substituted pyrazoles | �����ɷ� | 2004-06-23 | — | — | CN | disclosed |
| EP-1021416-B1 | METHOD FOR PRODUCING SUBSTITUTED PYRAZOLES | BASF AG (DE) | 2004-05-19 | — | — | EP | disclosed |
| US-6229022-B1 | REACTING CARBONYL COMPOUNDS WITH HYDRAZINE, ITS HYDRATE OR SALTS IN THE PRESENCE OF SULFURIC ACID AND IODINE OR AN IODINE LIBERATING COMPOUND | BASF AKTIENGESELLSCHAFT (DE) | 2001-05-08 | — | — | US | disclosed |
| EP-1021416-A1 | METHOD FOR PRODUCING SUBSTITUTED PYRAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 2000-07-26 | — | — | EP | disclosed |
| CN-1261351-A | Process for preparing substituted pyrazoles | BASF AG (DE) | 2000-07-26 | — | — | CN | disclosed |
| WO-1998058914-A1 | METHOD FOR PRODUCING SUBSTITUTED PYRAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 1998-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049603-A1 | Raf inhibitor compounds and methods of use thereof | BRAF, RAF1, ARAF | MEN1 852/4885KMT2A 3435/4885MAPT 574/4885 |
| US-20100016292-A1 | INHIBITORS OF LETHAL FACTOR PROTEASE | APAF1, F11, SERPINB1 | MEN1 1839/4885KMT2A 3345/4885MAPT 2957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.