SCHEMBL24499451

SCHEMBL24499451

O=c1c2ccn(Cc3ccccc3)c2ccn1Cc1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 2/20 0.54
EGLN1 Q9GZT9 5/20 0.52
DHPS P49366 1/20 0.51
MAPK14 Q16539 5/20 0.49
LMNA P02545 2/20 0.47
KDM4E B2RXH2 1/20 0.47
MEN1 O00255 1/20 0.47
ALDH1A1 P00352 1/20 0.47
MAPT P10636 1/20 0.47
KMT2A Q03164 1/20 0.47
APP P05067 1/20 0.47
SLC2A1 P11166 1/20 0.47
VEGFA P15692 1/20 0.47
HTT P42858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29696630 0.80 HTR6 (0.55) HTR6LMNAKDM4EMEN1ALDH1A1
SCHEMBL17111036 0.80 HTR6 (0.55) HTR6LMNAKDM4EMEN1ALDH1A1
SCHEMBL29809414 0.79 ACHE (0.59) EGLN1DHPSMAPK14LMNAKDM4E
SCHEMBL1757848 0.79 ACHE (0.59) EGLN1DHPSMAPK14LMNAKDM4E
SCHEMBL4147543 0.78 PARP1 (0.62) HTR6EGLN1DHPSMAPK14LMNA
SCHEMBL4056966 0.77 HTR6 (0.60) HTR6KDM4EMEN1ALDH1A1KMT2A
SCHEMBL29880153 0.77 HTR6 (0.60) HTR6KDM4EMEN1ALDH1A1KMT2A
SCHEMBL1774558 0.77 HTR6 (0.49) HTR6LMNAKDM4EMEN1ALDH1A1
SCHEMBL1775925 0.75 HTR6 (0.62) HTR6LMNAMEN1ALDH1A1KMT2A
SCHEMBL10269146 0.75 HTR6 (0.61) HTR6LMNAMEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240199543-A1 Aza-Substituted Psilocin Analogs And Methods Of Synthesizing The Same MYDECINE INNOVATIONS GROUP INC. 2024-06-20 US disclosed
US-11952342-B2 Aza-substituted psilocin analogs and methods of synthesizing the same MYDECINE INNOVATIONS GROUP INC. (US) 2024-04-09 US disclosed
US-20240101513-A1 Novel Aza-Substituted Psilocin Analogs And Methods Of Synthesizing The Same MYDECINE INNOVATIONS GROUP INC. 2024-03-28 US disclosed
US-11939292-B1 Aza-substituted psilocin analogs and methods of synthesizing the same MYDECINE INNOVATIONS GROUP INC. (US) 2024-03-26 US disclosed
US-11939292-B1 Aza-substituted psilocin analogs and methods of synthesizing the same MYDECINE INNOVATIONS GROUP INC. (US) 2024-03-26 US disclosed
US-11939292-B1 Aza-substituted psilocin analogs and methods of synthesizing the same MYDECINE INNOVATIONS GROUP INC. (US) 2024-03-26 US disclosed
US-20230348380-A1 Novel Aza-Substituted Psilocin Analogs And Methods Of Synthesizing The Same MYDECINE INNOVATIONS GROUP INC. 2023-11-02 US disclosed
US-20230348380-A1 Novel Aza-Substituted Psilocin Analogs And Methods Of Synthesizing The Same MYDECINE INNOVATIONS GROUP INC. 2023-11-02 US disclosed
US-20230348380-A1 Novel Aza-Substituted Psilocin Analogs And Methods Of Synthesizing The Same MYDECINE INNOVATIONS GROUP INC. 2023-11-02 US disclosed
US-20230271924-A1 Novel Psilocin Analog Compositions And Methods of Synthesizing The Same MYDECINE INNOVATIONS GROUP INC. 2023-08-31 US disclosed
US-20230271924-A1 Novel Psilocin Analog Compositions And Methods of Synthesizing The Same MYDECINE INNOVATIONS GROUP INC. 2023-08-31 US disclosed
US-20230271924-A1 Novel Psilocin Analog Compositions And Methods of Synthesizing The Same MYDECINE INNOVATIONS GROUP INC. 2023-08-31 US disclosed
WO-2023101722-A1 NOVEL AZA-SUBSTITUTED PSILOCIN ANALOGS AND METHODS OF SYNTHESIZING THE SAME MEDECINE INNOVATIONS GROUP INC. (US) 2023-06-08 WO disclosed
WO-2023101722-A1 NOVEL AZA-SUBSTITUTED PSILOCIN ANALOGS AND METHODS OF SYNTHESIZING THE SAME MEDECINE INNOVATIONS GROUP INC. (US) 2023-06-08 WO disclosed
WO-2022120181-A1 NOVEL PSILOCIN ANALOG COMPOSITIONS AND METHODS OF SYNTHESIZING THE SAME MYDECINE INNOVATIONS GROUP INC. (US) 2022-06-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240101513-A1 Novel Aza-Substituted Psilocin Analogs And Methods Of Synthesizing The Same TOP2A, PAICS, TOP1 HTR6 989/4885EGLN1 2949/4885DHPS 11/4885
US-20230348380-A1 Novel Aza-Substituted Psilocin Analogs And Methods Of Synthesizing The Same TOP2A, PAICS, TOP1 HTR6 989/4885EGLN1 2949/4885DHPS 11/4885
US-11952342-B2 Aza-substituted psilocin analogs and methods of synthesizing the same TOP2A, PAICS, TOP1 HTR6 963/4885EGLN1 2695/4885DHPS 17/4885
US-20230271924-A1 Novel Psilocin Analog Compositions And Methods of Synthesizing The Same PSAP, ABCG2, PSAT1 HTR6 429/4885EGLN1 1186/4885DHPS 7/4885
US-20240199543-A1 Aza-Substituted Psilocin Analogs And Methods Of Synthesizing The Same TOP2A, PAICS, TOP1 HTR6 963/4885EGLN1 2695/4885DHPS 17/4885
US-11939292-B1 Aza-substituted psilocin analogs and methods of synthesizing the same TOP2A, PAICS, TOP1 HTR6 963/4885EGLN1 2695/4885DHPS 17/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.