Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glutarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.77 |
| ▸ | TSHR | P16473 | 3/20 | 0.77 |
| ▸ | THRB | P10828 | 2/20 | 0.77 |
| ▸ | BLM | P54132 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.77 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.77 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.77 |
| ▸ | GABRP | O00591 | 1/20 | 0.77 |
| ▸ | GABRD | O14764 | 1/20 | 0.77 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.77 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.77 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.77 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.77 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.77 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.77 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.77 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.77 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutarate SCHEMBL143588 | 1.00 | LMNA (0.77) | LMNATSHRTHRBBLMKMT2A | |
| Glutarate SCHEMBL6815061 | 0.97 | LMNA (0.72) | LMNATSHRTHRBBLMKMT2A | |
| Glutarate SCHEMBL28335483 | 0.97 | LMNA (0.72) | LMNATSHRTHRBBLMKMT2A | |
| Adipic Acid SCHEMBL11328398 | 0.93 | NFKB1 (0.82) | LMNATSHRTHRBBLMKMT2A | |
| Adipic Acid SCHEMBL9133305 | 0.93 | NFKB1 (0.82) | LMNATSHRTHRBBLMKMT2A | |
| Adipic Acid SCHEMBL1647321 | 0.93 | NFKB1 (0.82) | LMNATSHRTHRBBLMKMT2A | |
| Glutarate SCHEMBL9453439 | 0.90 | LMNA (0.82) | LMNATSHRTHRBBLMKMT2A | |
| Glutarate SCHEMBL2915734 | 0.90 | LMNA (0.82) | LMNATSHRTHRBBLMKMT2A | |
| Azelaic Acid SCHEMBL11141213 | 0.90 | LMNA (0.83) | LMNATSHRTHRBBLMKMT2A | |
| Octanedioate SCHEMBL11875945 | 0.90 | LMNA (0.83) | LMNATSHRTHRBBLMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111303122-A | Pomalidomide derivative and application thereof | 南方医科大学 | 2020-06-19 | — | — | CN | claimed |
| CN-105772979-A | High flux environment-friendly tin wire and preparation method thereof | 苏州伊飞特电子科技有限公司 | 2016-07-20 | — | — | CN | claimed |
| CN-115812001-A | Azoxystrobin in sulfate-free personal care compositions | 宝洁公司 | 2023-03-17 | — | — | CN | disclosed |
| CN-115151310-A | Sulfur-containing anti-dandruff compositions with enhanced efficacy and aesthetics | 宝洁公司 | 2022-10-04 | — | — | CN | disclosed |
| CN-111303122-A | Pomalidomide derivative and application thereof | 南方医科大学 | 2020-06-19 | — | — | CN | disclosed |
| CN-111303122-A | Pomalidomide derivative and application thereof | 南方医科大学 | 2020-06-19 | — | — | CN | disclosed |
| CN-105772979-A | High flux environment-friendly tin wire and preparation method thereof | 苏州伊飞特电子科技有限公司 | 2016-07-20 | — | — | CN | disclosed |
| EP-1546297-B1 | HIGH CONCENTRATION SURFACTANT COMPOSITIONS AND METHODS | RHODIA OPERATIONS (FR) | 2011-09-28 | — | — | EP | disclosed |
| US-7449435-B2 | High concentration surfactant compositions and methods | MCINTYRE GROUP, LTD. (US) | 2008-11-11 | — | — | US | disclosed |
| US-20070270326-A1 | High concentration surfactant compositions and methods | MCINTYRE GROUP, LTD. | 2007-11-22 | — | — | US | disclosed |
| US-7256164-B2 | High concentration surfactant compositions and methods | MCINTYRE GROUP, LTD. (US) | 2007-08-14 | — | — | US | disclosed |
| EP-1546297-A4 | HIGH CONCENTRATION SURFACTANT COMPOSITIONS AND METHODS | MCINTYRE GROUP LTD (US) | 2006-06-07 | — | — | EP | disclosed |
| EP-1546297-A2 | HIGH CONCENTRATION SURFACTANT COMPOSITIONS AND METHODS | McINTYRE GROUP, LTD. (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20050037942-A1 | High concentration surfactant compositions and methods | RHODIA OPERATIONS (FR) | 2005-02-17 | — | — | US | disclosed |
| WO-2004015047-A2 | HIGH CONCENTRATION SURFACTANT COMPOSITIONS AND METHODS | MCINTYRE GROUP, LTD. (US) | 2004-02-19 | — | — | WO | disclosed |