Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | GLS | O94925 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24501584 | 1.00 | LRRK2 (0.32) | LRRK2CNR2POLBGAAHSD11B1 | |
| SCHEMBL29694716 | 1.00 | LRRK2 (0.32) | LRRK2CNR2POLBGAAHSD11B1 | |
| SCHEMBL22717781 | 0.84 | POLB (0.40) | POLBGAAGLS | |
| SCHEMBL24501232 | 0.82 | KDM5A (0.33) | LRRK2POLBGAA | |
| SCHEMBL24501494 | 0.80 | POLB (0.47) | POLBGAAGLS | |
| SCHEMBL19449335 | 0.80 | POLB (0.44) | POLBGAAGLS | |
| SCHEMBL24500857 | 0.78 | POLB (0.35) | POLBGAA | |
| SCHEMBL24501285 | 0.77 | POLB (0.35) | POLBGAAGLS | |
| SCHEMBL24501049 | 0.76 | DHFR (0.39) | POLBGAAGLS | |
| SCHEMBL29108540 | 0.74 | FEN1 (0.35) | CNR2POLBGAAGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022118210-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-06-09 | — | — | WO | disclosed |