Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24501049 | 0.82 | DHFR (0.39) | POLBGAADHFRDCPS | |
| SCHEMBL22717711 | 0.81 | POLB (0.45) | POLBGAALMNAMAPTRAB9A | |
| SCHEMBL27294311 | 0.77 | MCHR1 (0.43) | POLBGAADHFRDCPS | |
| SCHEMBL31083249 | 0.72 | GLS (0.33) | POLBGAADHFRDCPSRAB9A | |
| SCHEMBL22717781 | 0.71 | POLB (0.40) | POLBGAARAB9A | |
| SCHEMBL18010480 | 0.71 | POLB (0.71) | POLBGAA | |
| SCHEMBL11555746 | 0.70 | RAB9A (0.57) | LMNAMAPTRAB9A | |
| SCHEMBL24501428 | 0.69 | POLB (0.33) | POLBGAA | |
| SCHEMBL24501285 | 0.68 | POLB (0.35) | POLBGAA | |
| SCHEMBL29108213 | 0.68 | POLB (0.32) | POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022118210-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-06-09 | — | — | WO | disclosed |