Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.57 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1318501 | 0.85 | CYP1A2 (0.56) | CRHBPCRHR2PDPK1ROCK1AURKB | |
| SCHEMBL2448685 | 0.82 | CRHBP (0.61) | CRHBPCRHR2PDPK1ROCK1AURKB | |
| SCHEMBL6603334 | 0.81 | CRHBP (0.51) | CRHBPCRHR2PDPK1ROCK1AURKB | |
| SCHEMBL1319013 | 0.74 | PDPK1 (0.57) | CRHBPCRHR2PDPK1ROCK1AURKB | |
| SCHEMBL21516848 | 0.74 | CRHBP (0.55) | CRHBPCRHR2PDPK1ROCK1AURKB | |
| SCHEMBL21516206 | 0.74 | CRHBP (0.55) | CRHBPCRHR2PDPK1ROCK1AURKB | |
| SCHEMBL5789932 | 0.73 | CRHBP (1.00) | CRHBPCRHR2SMN1; SMN2HRH3HRH4 | |
| SCHEMBL25563478 | 0.73 | AURKA (0.46) | PDPK1ROCK1AURKBAURKAPIK3C3 | |
| SCHEMBL25567517 | 0.73 | AURKA (0.46) | PDPK1ROCK1AURKBAURKAPIK3C3 | |
| SCHEMBL25563470 | 0.73 | AURKA (0.46) | PDPK1ROCK1AURKBAURKAPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-09-07 | — | — | EP | disclosed |