SCHEMBL24503003

SCHEMBL24503003

COC(=O)CCc1ccc2c(c1)oc1cc(F)ccc12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 1/20 0.45
CYP11B1 P15538 2/20 0.43
CYP11B2 P19099 2/20 0.43
CA12 O43570 1/20 0.41
CA2 P00918 1/20 0.41
CA7 P43166 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41
KDM4E B2RXH2 2/20 0.40
ALDH1A1 P00352 2/20 0.40
KMT2A Q03164 2/20 0.40
GLA P06280 1/20 0.40
GAA P10253 1/20 0.40
MEN1 O00255 1/20 0.40
ATM Q13315 1/20 0.40
MCHR1 Q99705 2/20 0.40
ROCK2 O75116 1/20 0.40
HPGD P15428 2/20 0.40
FFAR4 Q5NUL3 2/20 0.39
RXFP1 Q9HBX9 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24503006 0.82 MPO (0.45) CYP11B1CYP11B2MCHR1ROCK2HPGD
SCHEMBL16595321 0.79 LMNA (0.51) CNR2CYP11B1CYP11B2CA12CA2
SCHEMBL2723440 0.77 CYP11B1 (0.57) CNR2CYP11B1CYP11B2CA12CA2
SCHEMBL901672 0.75 TAAR1 (0.53) CNR2FFAR1
SCHEMBL1841248 0.73 CYP11B1 (0.53) CNR2CYP11B1CYP11B2CA12CA2
SCHEMBL30228194 0.72 KCNA3 (0.48) CA12CA9KDM4EALDH1A1KMT2A
SCHEMBL22922181 0.72 CYP4F2 (0.59) CA12CA7CA9CA14ALDH1A1
SCHEMBL21617914 0.71 LMNA (0.60) KDM4EALDH1A1KMT2A
SCHEMBL3683799 0.71 ALOX5 (0.51) ALDH1A1GAA
SCHEMBL1255726 0.71 PTPN1 (0.46) CYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4257588-A1 SMALL MOLECULE INHIBITOR OF CATHEPSIN C AND MEDICINAL USE THEREOF Reistone Biopharma Company Limited (CN) 2023-10-11 EP disclosed
WO-2022117059-A1 SMALL MOLECULE INHIBITOR OF CATHEPSIN C AND MEDICINAL USE THEREOF 瑞石生物医药有限公司 2022-06-09 WO disclosed