Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 9/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | QDPR | P09417 | 1/20 | 0.37 |
| ▸ | LPL | P06858 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12302215 | 0.95 | HIF1A (0.44) | NAMPTHIF1AUSP30ALDH1A1DGAT1 | |
| SCHEMBL586426 | 0.87 | HIF1A (0.42) | NAMPTHIF1AUSP30ROCK1QDPR | |
| SCHEMBL15788273 | 0.87 | QDPR (0.51) | NAMPTHIF1AUSP30ALDH1A1DGAT1 | |
| SCHEMBL24504542 | 0.86 | HIF1A (0.42) | NAMPTHIF1AUSP30ALDH1A1ROCK1 | |
| SCHEMBL15615608 | 0.84 | HIF1A (0.47) | NAMPTHIF1AUSP30DGAT1QDPR | |
| SCHEMBL15656742 | 0.82 | TDP1 (0.58) | NAMPTALDH1A1MEN1KMT2A | |
| SCHEMBL18318497 | 0.81 | LMNA (0.48) | NAMPTKMT2A | |
| SCHEMBL180435 | 0.81 | USP30 (0.56) | NAMPTUSP30ALDH1A1 | |
| SCHEMBL15615620 | 0.81 | GPR119 (0.47) | NAMPTHIF1AUSP30 | |
| SCHEMBL578423 | 0.79 | QDPR (0.44) | HIF1AQDPRLPLLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022122913-A1 | SUBSTITUTED PYRAZOLO PIPERIDINE CARBOXYLIC ACIDS | BAYER AKTIENGESELLSCHAFT (DE) | 2022-06-16 | — | — | WO | disclosed |
| WO-2022122916-A1 | SUBSTITUTED PYRAZOLYL PIPERIDINE CARBOXYLIC ACIDS | BAYER AKTIENGESELLSCHAFT (DE) | 2022-06-16 | — | — | WO | disclosed |
| EP-4011874-A1 | SUBSTITUTED PYRAZOLO PIPERIDINE CARBOXYLIC ACIDS | Bayer Aktiengesellschaft (DE) | 2022-06-15 | — | — | EP | disclosed |