⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24506572 | 0.80 | CCNA2 (0.36) | — | |
| SCHEMBL24506792 | 0.75 | HTR1D (0.33) | — | |
| SCHEMBL24506887 | 0.75 | NOS3 (0.36) | — | |
| SCHEMBL24506573 | 0.74 | PRMT1 (0.30) | — | |
| SCHEMBL24506793 | 0.72 | — | — | |
| SCHEMBL24506565 | 0.69 | HTR1D (0.33) | — | |
| SCHEMBL25449340 | 0.68 | NOS3 (0.36) | — | |
| SCHEMBL24506571 | 0.68 | TGFBR1 (0.38) | — | |
| SCHEMBL1551266 | 0.67 | TLR9 (0.42) | — | |
| SCHEMBL24604964 | 0.66 | NQO2 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212143-A9 | PRMT5 INHIBITOR COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2023-07-06 | — | — | US | disclosed |
| US-20220185792-A1 | PRMT5 INHIBITOR COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2022-06-16 | — | — | US | disclosed |