Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 5/20 | 0.46 |
| ▸ | IKBKB | O14920 | 3/20 | 0.46 |
| ▸ | HTR6 | P50406 | 4/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 3/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.42 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.42 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.42 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.42 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650016 | 0.94 | PRKCZ (0.49) | ROCK1HTR6HTR1ADRD2HTR2A | |
| SCHEMBL4650913 | 0.87 | ROCK1 (0.51) | ROCK1IKBKBHTR6HTR1ADRD2 | |
| SCHEMBL4650745 | 0.85 | HTR6 (0.47) | HTR6HTR2AHTR2B | |
| SCHEMBL4650006 | 0.82 | HTR6 (0.44) | HTR6HTR2AHTR2BCHEK2 | |
| SCHEMBL4650101 | 0.82 | HTR6 (0.44) | HTR6HTR2AHTR2BCHEK2 | |
| SCHEMBL2450284 | 0.81 | HTR6 (0.47) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL4649412 | 0.79 | CHRM2 (0.45) | ROCK1HTR6HTR2AROCK2HTR2B | |
| SCHEMBL4648947 | 0.78 | HTR6 (0.58) | ROCK1IKBKBHTR6HTR1ADRD2 | |
| SCHEMBL4649974 | 0.77 | CHRM2 (0.43) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL4650621 | 0.77 | LTA4H (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730112-B1 | 3-((HETERO)ARYLSULFONYL)-8'[ (AMINOALKYL)OXY]QUINOLINES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2008-09-03 | — | — | EP | claimed |