Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 12/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.35 |
| ▸ | USP2 | O75604 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23568282 | 0.86 | CYP2D6 (0.49) | CYP2D6SMN1; SMN2CYP3A4USP2CYP1A2 | |
| SCHEMBL23560443 | 0.83 | TSHR (0.42) | CYP2D6SMN1; SMN2CYP3A4USP2CYP1A2 | |
| SCHEMBL24673650 | 0.83 | TSHR (0.42) | CYP2D6SMN1; SMN2CYP3A4USP2CYP1A2 | |
| SCHEMBL25728844 | 0.82 | DRD2 (0.33) | CYP2D6SMN1; SMN2 | |
| SCHEMBL23842008 | 0.81 | CYP2D6 (0.35) | CYP2D6SMN1; SMN2CYP3A4USP2CYP1A2 | |
| SCHEMBL24607411 | 0.81 | PIK3CD (0.34) | SMN1; SMN2 | |
| SCHEMBL26170521 | 0.80 | CYP2D6 (0.49) | CYP2D6SMN1; SMN2CYP3A4USP2CYP1A2 | |
| SCHEMBL22856409 | 0.79 | DRD2 (0.42) | CYP2D6 | |
| SCHEMBL24555490 | 0.78 | CYP2D6 (0.35) | CYP2D6CYP3A4USP2CYP1A2 | |
| SCHEMBL23132218 | 0.77 | CYP2D6 (0.37) | CYP2D6SMN1; SMN2CYP3A4USP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125790-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |