Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | DHODH | Q02127 | 7/20 | 0.53 |
| ▸ | CDC7 | O00311 | 4/20 | 0.50 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1340195 | 0.89 | TRPM8 (0.65) | TRPM8ALDH1A1HPGDHSD17B10DHODH | |
| SCHEMBL24508984 | 0.87 | ALDH1A1 (0.73) | TRPM8ALDH1A1HPGDHSD17B10DHODH | |
| SCHEMBL1920374 | 0.85 | TRPM8 (0.64) | TRPM8ALDH1A1HPGDHSD17B10DHODH | |
| SCHEMBL1919084 | 0.84 | ALDH1A1 (0.74) | TRPM8ALDH1A1HPGDHSD17B10DHODH | |
| SCHEMBL1919770 | 0.82 | FNTA (0.55) | TRPM8ALDH1A1HPGDHSD17B10DHODH | |
| SCHEMBL2690701 | 0.81 | CDC7 (0.48) | TRPM8ALDH1A1HPGDHSD17B10DHODH | |
| SCHEMBL14705596 | 0.80 | PTGDR2 (0.48) | TRPM8CDC7DBF4MEN1KMT2A | |
| SCHEMBL16075311 | 0.79 | ALDH1A1 (0.59) | TRPM8ALDH1A1HPGDHSD17B10DHODH | |
| SCHEMBL24508625 | 0.79 | TRPM8 (0.59) | TRPM8ALDH1A1HPGDHSD17B10DHODH | |
| SCHEMBL15048962 | 0.78 | TRPM8 (1.00) | TRPM8CDC7DBF4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4259620-A1 | ALDEHYDE DEHYDROGENASE INHIBITORS AND THEIR THERAPEUTIC USE | Cancer Research Technology Limited (GB) | 2023-10-18 | — | — | EP | disclosed |
| WO-2022123039-A1 | ALDEHYDE DEHYDROGENASE INHIBITORS AND THEIR THERAPEUTIC USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2022-06-16 | — | — | WO | disclosed |
| WO-2022123039-A1 | ALDEHYDE DEHYDROGENASE INHIBITORS AND THEIR THERAPEUTIC USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2022-06-16 | — | — | WO | disclosed |