Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.32 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | OXTR | P30559 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2451435 | 0.90 | PIK3CA (0.34) | GRM5KCNH2PIK3CASTIM1ORAI1 | |
| SCHEMBL2451262 | 0.88 | PIK3CA (0.35) | GRM5POLBPIK3CASTIM1ORAI1 | |
| SCHEMBL2453877 | 0.87 | POLB (0.36) | POLBCYP11B2CHRNB4CHRNA3IDO1 | |
| SCHEMBL2452981 | 0.85 | OXTR (0.46) | OXTR | |
| SCHEMBL1074623 | 0.84 | PIK3CA (0.41) | KCNH2POLBPIK3CA | |
| SCHEMBL1074256 | 0.82 | GRM1 (0.43) | KCNH2CYP11B2IDO1TDO2 | |
| SCHEMBL2452818 | 0.81 | PIK3CA (0.41) | PIK3CAMTORCYP11B2GLA | |
| SCHEMBL2450998 | 0.79 | PTGS2 (0.40) | POLBOXTRCHRNB4CHRNA3 | |
| SCHEMBL1074563 | 0.79 | NOTUM (0.37) | GLA | |
| SCHEMBL2448152 | 0.78 | PIK3CA (0.35) | GRM5PIK3CASTIM1ORAI1OXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110311649-A1 | NOVEL IMIDAZOLE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2011-12-22 | — | — | US | claimed |
| EP-2201001-B1 | NOVEL IMIDAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-09-14 | — | — | EP | claimed |
| EP-2201001-A1 | NOVEL IMIDAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2010-06-30 | — | — | EP | claimed |
| WO-2009053101-A1 | NOVEL IMIDAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-04-30 | — | — | WO | claimed |
| EP-2053044-A1 | Novel imidazole derivatives | Syngenta Participations AG (CH) | 2009-04-29 | — | — | EP | claimed |
| EP-2053046-A1 | Novel imidazole derivatives | Syngeta Participations AG (CH) | 2009-04-29 | — | — | EP | claimed |
| WO-2018048969-A1 | MULTI-TARGETED HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2018-03-15 | — | — | WO | disclosed |
| EP-2654433-B1 | SANDPAPER MUTANTS OF BACILLUS AND METHODS OF THEIR USE TO ENHANCE PLANT GROWTH, PROMOTE PLANT HEALTH AND CONTROL DISEASES AND PESTS | BAYER CROPSCIENCE LP (US) | 2017-08-30 | — | — | EP | disclosed |
| US-20160095321-A1 | SANDPAPER MUTANTS OF BACILLUS AND METHODS OF THEIR USE TO ENHANCE PLANT GROWTH, PROMOTE PLANT HEALTH AND CONTROL DISEASES AND PESTS | AGRAQUEST, INC. | 2016-04-07 | — | — | US | disclosed |
| US-9185915-B2 | Sandpaper mutants of bacillus and methods of their use to enhance plant growth, promote plant health and control diseases and pests | BAYER CROPSCIENCE LP (US) | 2015-11-17 | — | — | US | disclosed |
| EP-2654433-A1 | SANDPAPER MUTANTS OF BACILLUS AND METHODS OF THEIR USE TO ENHANCE PLANT GROWTH, PROMOTE PLANT HEALTH AND CONTROL DISEASES AND PESTS | Bayer Cropscience LP (US) | 2013-10-30 | — | — | EP | disclosed |
| US-20120231951-A1 | SANDPAPER MUTANTS OF BACILLUS AND METHODS OF THEIR USE TO ENHANCE PLANT GROWTH, PROMOTE PLANT HEALTH AND CONTROL DISEASES AND PESTS | BAYER CROPSCIENCE LP | 2012-09-13 | — | — | US | disclosed |
| WO-2012087980-A1 | SANDPAPER MUTANTS OF BACILLUS AND METHODS OF THEIR USE TO ENHANCE PLANT GROWTH, PROMOTE PLANT HEALTH AND CONTROL DISEASES AND PESTS | AGRAQUEST, INC. (US) | 2012-06-28 | — | — | WO | disclosed |
| US-20110311649-A1 | NOVEL IMIDAZOLE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2011-12-22 | — | — | US | disclosed |
| EP-2201001-B1 | NOVEL IMIDAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-09-14 | — | — | EP | disclosed |
| EP-2201001-A1 | NOVEL IMIDAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009053101-A1 | NOVEL IMIDAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-04-30 | — | — | WO | disclosed |
| EP-2053044-A1 | Novel imidazole derivatives | Syngenta Participations AG (CH) | 2009-04-29 | — | — | EP | disclosed |
| EP-2053046-A1 | Novel imidazole derivatives | Syngeta Participations AG (CH) | 2009-04-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110311649-A1 | NOVEL IMIDAZOLE DERIVATIVES | CBR3, C3AR1, C1R | GRM5 3305/4885KCNH2 72/4885POLB 4592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.